HCK and PIK3CB

Number of citations of the paper that reports this interaction (PubMedID 12029088)
0

Data Source:
HPRD (in vitro)

		HCK	PIK3CB
Description		HCK proto-oncogene, Src family tyrosine kinase	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Caveola Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Cell Projection Membrane Raft Anchoring Junction	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Midbody
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Protein Serine Kinase Activity
	Biological Process	Immune System Process Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Exocytosis Phagocytosis Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Inflammatory Response Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Type II Interferon-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Podosome Assembly	Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Leukocyte Mediated Immunity Response To Ischemia Sphingosine-1-phosphate Receptor Signaling Pathway Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Endocytosis Autophagy Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Migration Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Embryonic Cleavage Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Platelet Aggregation Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Clathrin-dependent Endocytosis
Pathways		Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF1 (M-CSF) in myeloid cells Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib Fostamatinib	Caffeine XL765
Diseases
GWAS		Adult body size ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543)	Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494)
Interacting Genes		117 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK AGR2 APP AR ARRB1 ASAP1 BCAR1 BCR BPIFA1 BTK CBL CCDC88B CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK CTAG1A CTAG1B CYB5D2 CYSRT1 DNM2 DOK1 DOK2 EGFR ELMO1 ERBB2 ERBB3 ERBB4 EVL FASLG FCGR1A FCGR2A FHL2 FHL5 GAB1 GOPC GRB14 HNRNPK HSF2BP IL6ST INCA1 INPP5D IRF2BPL KHDRBS1 KIT KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 LCP2 LETMD1 LMNA MAP4K5 MDK MDM2 MET MID2 MKRN3 MTUS2 NBPF19 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLEKHG4 PNMA1 PRRG4 RAPGEF1 RASA1 RASA3 RBPMS RPL10 SF3B3 SH2B2 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TEKT4 TEPSIN TNK2 TOX2 TP73 TRIM27 TRIP6 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2 ZSCAN4	13 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 LRRK2 MME PIK3R1 PIK3R2 PRKCD PRKCE RAB5B YWHAQ
Entrez ID		3055	5291
HPRD ID		00796	04234
Ensembl ID		ENSG00000101336	ENSG00000051382
Uniprot IDs		A8K4G3 P08631	B4DER4 P42338
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6 8F2P 9BYJ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway SH3 Domain Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Endocytosis Intracellular Signaling Cassette Cytosol Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Keratin Filament Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Activity ERBB Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Protein Binding Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Intermediate Filament Regulation Of Immune System Process Plasma Membrane Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Negative Regulation Of Programmed Cell Death Cell-cell Junction Developmental Process Regulation Of Cell Motility Regulation Of Immune Response Actin Filament Organization Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Locomotion Identical Protein Binding Endocytosis	Intracellular Signaling Cassette Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Biological Quality Regulation Of Cytoskeleton Organization Exploration Behavior Regulation Of Actin Filament Polymerization Fc-gamma Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Import Into Nucleus Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Transport Phosphotyrosine Residue Binding Regulation Of Supramolecular Fiber Organization Regulation Of Kidney Size Cellular Response To Peptide Hormone Stimulus 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Organelle Organization Fc Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cellular Response To Oxygen-containing Compound Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Size Cellular Response To UV Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Insulin Receptor Substrate Binding Cellular Response To Insulin Stimulus Positive Regulation Of Protein Localization To Nucleus Locomotory Exploration Behavior Response To Peptide Hormone Cellular Response To Light Stimulus Protein Transport
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