HCK and PIK3CB

Number of citations of the paper that reports this interaction (PMID 12029088)
18

Data Source:
HPRD (in vitro)

		HCK	PIK3CB
Gene Name		HCK proto-oncogene, Src family tyrosine kinase	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Golgi Apparatus Cytosol Actin Filament Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection	Nucleus Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	Activation Of MAPK Activity Regulation Of Cell-matrix Adhesion Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cellular Calcium Ion Homeostasis Autophagy Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cell Migration Platelet Activation Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Embryonic Cleavage Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Platelet Aggregation Regulation Of Clathrin-mediated Endocytosis
Pathways		HIV Infection Host Interactions of HIV factors Cytokine Signaling in Immune system The role of Nef in HIV-1 replication and disease pathogenesis Nef and signal transduction Signaling by Interleukins Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Interleukin-3, 5 and GM-CSF signaling FCGR activation Innate Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by Interleukins Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Downstream TCR signaling IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2	10 interactors: AGTR2 ALAS1 DVL3 HCK HPS6 MME PIK3R1 PRKCD PRKCE YWHAQ
Entrez ID		3055	5291
HPRD ID		00796	04234
Ensembl ID		ENSG00000101336
Uniprot IDs		A8K4G3 P08631	B4DER4 P42338
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Blood Coagulation Response To Stimulus Defense Response Regulation Of Immune Response Hemostasis Wound Healing Immune System Process Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Antigen Receptor-mediated Signaling Pathway Response To Wounding Positive Regulation Of Immune Response Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Body Fluid Levels Locomotion Regulation Of Immune System Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Vesicle-mediated Transport Response To Stress Regulation Of Signal Transduction Regulation Of Cellular Process Platelet Activation Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Signaling Response To External Stimulus Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Receptor Activity Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Lipid Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Exploration Behavior Platelet Activation Response To Fibroblast Growth Factor Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Wound Healing Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Endocytosis Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Wounding Cellular Localization Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Dephosphorylation Activation Of Phospholipase C Activity Response To Organic Substance Regulation Of Lipid Metabolic Process Regulation Of Protein Localization
Tagcloud ?		32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?