HCK and RAPGEF1

  • Number of citations of the paper that reports this interaction (PMID 10318861)
  • 19
  • Data Source:
  • HPRD (in vitro, in vivo)

HCK

RAPGEF1

Gene Name HCK proto-oncogene, Src family tyrosine kinase Rap guanine nucleotide exchange factor (GEF) 1
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions 69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2 16 interactors: ABL1 ATXN1 BCAR1 CRK CRKL GRB2 HCK HRAS MBIP NEDD9 RAP1B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID 3055 2889
HPRD ID 00796 02627
Ensembl ID ENSG00000101336 ENSG00000107263
Uniprot IDs A8K4G3 P08631 Q13905 Q68DL3
PDB IDs 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
32dcl3  32p  antisera  cbl  eliminated  engagement  fusion  fyn  gst  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
abl  abrogated  c3g  catalytically  colocalized  crk  delineate  dephosphorylation  forskolin  golgi  guanine  imr  interacted  neurite  neuroblastoma  noncatalytic  outgrowth  pc3g  pervanadate  phospho  ptp  ptpn2  reorganization  src  substrate  tc  tc48  vanadate  y504 
Tagcloud (Difference) ?
32dcl3  32p  antisera  cbl  eliminated  engagement  fusion  fyn  gst  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
abl  abrogated  c3g  catalytically  colocalized  crk  delineate  dephosphorylation  forskolin  golgi  guanine  imr  interacted  neurite  neuroblastoma  noncatalytic  outgrowth  pc3g  pervanadate  phospho  ptp  ptpn2  reorganization  src  substrate  tc  tc48  vanadate  y504 
Tagcloud (Intersection) ?