HCK and RAPGEF1

Number of citations: 0 (PubMedID 14551197)
Data Source: HPRD (in vivo, in vitro)

		HCK	RAPGEF1
Name		HCK proto-oncogene, Src family tyrosine kinase	Rap guanine nucleotide exchange factor 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Caveola Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Cell Projection Membrane Raft Anchoring Junction	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Immune System Process Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Exocytosis Phagocytosis Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Inflammatory Response Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Type II Interferon-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Podosome Assembly	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways		Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib Fostamatinib	None
GWAS		Adult body size ( 32376654 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Migraine ( 27322543 )	Cerebrospinal fluid α-synuclein levels ( 29959729 ) Cutaneous malignant melanoma ( 32341527 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Kidney volume ( 34128465 ) Nevus count or cutaneous melanoma ( 32341527 ) Optic disc size ( 31809533 )
Novel Interactors		1 novel interactors: COMT	1 novel interactors: PDGFRA
Interacting Genes		117 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK AGR2 APP AR ARRB1 ASAP1 BCAR1 BCR BPIFA1 BTK CBL CCDC88B CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK CTAG1A CTAG1B CYB5D2 CYSRT1 DNM2 DOK1 DOK2 EGFR ELMO1 ERBB2 ERBB3 ERBB4 EVL FASLG FCGR1A FCGR2A FHL2 FHL5 GAB1 GOPC GRB14 HNRNPK HSF2BP IL6ST INCA1 INPP5D IRF2BPL KHDRBS1 KIT KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 LCP2 LETMD1 LMNA MAP4K5 MDK MDM2 MET MID2 MKRN3 MTUS2 NBPF19 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLEKHG4 PNMA1 PRRG4 RAPGEF1 RASA1 RASA3 RBPMS RPL10 SF3B3 SH2B2 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TEKT4 TEPSIN TNK2 TOX2 TP73 TRIM27 TRIP6 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2 ZSCAN4	19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		3055	2889
HPRD ID		00796	02627
Ensembl ID		ENSG00000101336	ENSG00000107263
Uniprot IDs		A8K4G3 P08631	A0A1S5UYZ7 A0A804HL87 Q13905
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6 8F2P 9BYJ	5L23
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway SH3 Domain Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Endocytosis Intracellular Signaling Cassette Cytosol Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Keratin Filament Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Activity ERBB Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Protein Binding Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Intermediate Filament Regulation Of Immune System Process Plasma Membrane Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Negative Regulation Of Programmed Cell Death Cell-cell Junction Developmental Process Regulation Of Cell Motility Regulation Of Immune Response Actin Filament Organization Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Locomotion Identical Protein Binding Endocytosis	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Small GTPase-mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament-based Process Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway GDP Binding Regulation Of Protein Localization To Membrane Regulation Of Cell Migration Response To Growth Factor Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Locomotion Positive Regulation Of Signaling Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Rap Protein Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Focal Adhesion Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Lymphocyte Migration Cytosol Cell Motility GTPase Activity