HCK and DOK1

Number of citations of the paper that reports this interaction (PMID 11071635)
19

Data Source:
HPRD (in vitro)

		HCK	DOK1
Gene Name		HCK proto-oncogene, Src family tyrosine kinase	docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Golgi Apparatus Cytosol Actin Filament Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway
Pathways		HIV Infection Host Interactions of HIV factors Cytokine Signaling in Immune system The role of Nef in HIV-1 replication and disease pathogenesis Nef and signal transduction Signaling by Interleukins Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Interleukin-3, 5 and GM-CSF signaling FCGR activation Innate Immune System	IRS-related events triggered by IGF1R Insulin receptor signalling cascade IRS activation IRS-mediated signalling Signal attenuation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events IGF1R signaling cascade PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2	39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1
Entrez ID		3055	1796
HPRD ID		00796	04228
Ensembl ID		ENSG00000101336	ENSG00000115325
Uniprot IDs		A8K4G3 P08631	B3KP83 B4DJN1 Q2TA81 Q99704
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK	2V76
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Blood Coagulation Response To Stimulus Defense Response Regulation Of Immune Response Hemostasis Wound Healing Immune System Process Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Antigen Receptor-mediated Signaling Pathway Response To Wounding Positive Regulation Of Immune Response Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Body Fluid Levels Locomotion Regulation Of Immune System Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Vesicle-mediated Transport Response To Stress Regulation Of Signal Transduction Regulation Of Cellular Process Platelet Activation Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Signaling Response To External Stimulus Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Locomotion Cell Migration Immune System Process Cell Surface Receptor Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Leukocyte Migration Innate Immune Response Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response Defense Response Wound Healing Blood Coagulation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Hemostasis Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Response To Wounding Cellular Response To Stimulus Single Organismal Cell-cell Adhesion Cellular Response To Organic Substance Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Activation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Regulation Of Cell Adhesion Response To Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling
Tagcloud ?		32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine proline sh2 sh3 thymoma tyr731 yeam	adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?		phosphotyrosine