HCK and DOK1

  • Number of citations of the paper that reports this interaction (PMID 11071635)
  • 19
  • Data Source:
  • HPRD (in vitro)

HCK

DOK1

Gene Name HCK proto-oncogene, Src family tyrosine kinase docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions 69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2 39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1
Entrez ID 3055 1796
HPRD ID 00796 04228
Ensembl ID ENSG00000101336 ENSG00000115325
Uniprot IDs A8K4G3 P08631 B3KP83 B4DJN1 Q2TA81 Q99704
PDB IDs 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK 2V76
Enriched GO Terms of Interacting Partners?
Tagcloud ?
32dcl3  32p  antisera  cbl  eliminated  engagement  fusion  fyn  gst  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
adaptors  coimmunoprecipitated  comprises  epcs  epo  epor  erythroblast  erythroblasts  gab1  hemoglobinizing  homo  irs2  orf  phosphoproteomics  phosphotyrosine  primates  propagates  py  rhex  sapiens  sh2d2a  shc1  sprouty  spry1  spry2  stam2  transducing  ut7epo  validating 
Tagcloud (Difference) ?
32dcl3  32p  antisera  cbl  eliminated  engagement  fusion  fyn  gst  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  proline  sh2  sh3  thymoma  tyr731  yeam 
adaptors  coimmunoprecipitated  comprises  epcs  epo  epor  erythroblast  erythroblasts  gab1  hemoglobinizing  homo  irs2  orf  phosphoproteomics  primates  propagates  py  rhex  sapiens  sh2d2a  shc1  sprouty  spry1  spry2  stam2  transducing  ut7epo  validating 
Tagcloud (Intersection) ?
phosphotyrosine