TRPC5 and NHERF1

Number of citations of the paper that reports this interaction (PubMedID 10980202)
0

Data Source:
HPRD (in vitro, in vivo)

		TRPC5	NHERF1
Description		transient receptor potential cation channel subfamily C member 5	NHERF family PDZ scaffold protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Presynapse	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex
	Molecular Function	Actin Binding Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases			Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Smoking behavior ( 19247474)
Interacting Genes		9 interacting genes: DRD2 ENKUR ITPR3 MX1 NHERF1 STMN2 STMN3 TRPC1 TRPC4	67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468
Entrez ID		7224	9368
HPRD ID		02273	05406
Ensembl ID		ENSG00000072315	ENSG00000109062
Uniprot IDs		Q9UL62	O14745
PDB IDs		6YSN 7D4P 7D4Q 7E4T 7WDB 7X6C 7X6I 8GVW 8GVX	1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Acid Secretion Inorganic Ion Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Calcium Ion Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Metal Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Gamma-aminobutyric Acid Transport Monoatomic Cation Transport Cation Channel Complex Microtubule Depolymerization Regulation Of Sequestering Of Calcium Ion Chemical Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Ion Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Intracellular Chemical Homeostasis Protein Depolymerization Microtubule Polymerization Or Depolymerization Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Cellular Homeostasis Carboxylic Acid Transport Organic Acid Transport Homeostatic Process Inorganic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Structural Constituent Of Presynaptic Actin Cytoskeleton Renal Phosphate Ion Absorption Tubulin Binding Monoatomic Ion Transmembrane Transport Regulation Of Sodium Ion Transport Response To Metal Ion Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Organic Anion Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Phenol-containing Compound Metabolic Process Apical Part Of Cell	Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?