TRPC5 and TRPC4

Number of citations of the paper that reports this interaction (PMID 12032305)
131

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vitro, in vivo)

		TRPC5	TRPC4
Gene Name		transient receptor potential cation channel, subfamily C, member 5	transient receptor potential cation channel, subfamily C, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Calcium Channel Complex	Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Calcium Channel Complex
	Molecular Function	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Nervous System Development Axon Guidance Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport	Calcium Ion Transport Axon Guidance Gamma-aminobutyric Acid Secretion Ion Transmembrane Transport Oligodendrocyte Differentiation Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling	Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling
Drugs
Diseases
GWAS		Smoking behavior ( 19247474)	Age-related macular degeneration ( 23326517) Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: ITPR3 MX1 SLC9A3R1 STMN2 STMN3 TRPC1 TRPC4	9 interactors: ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID		7224	7223
HPRD ID		02273	09154
Ensembl ID		ENSG00000072315	ENSG00000133107
Uniprot IDs		Q9UL62	Q3KR50 Q9UBN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Transport Metal Ion Transport Calcium Ion Transport Acid Secretion Cell Projection Organization Cation Transport Regulation Of Microtubule Polymerization Or Depolymerization Cellular Ion Homeostasis Renal Phosphate Ion Absorption Cellular Chemical Homeostasis Ion Homeostasis Response To Calcium Ion Generation Of Neurons Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Secretion Monocarboxylic Acid Transport Neurogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Homeostasis Ion Transport Regulation Of Microtubule-based Process Gamma-aminobutyric Acid Secretion Cytosolic Calcium Ion Homeostasis Neuron Projection Development Renal Sodium Ion Transport Positive Regulation Of Microtubule Depolymerization Chemical Homeostasis Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Sensory Perception Of Sweet Taste Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Cation Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Rac Protein Signal Transduction Sensory Perception Of Umami Taste Neuron Development Nervous System Development Phospholipase C-activating Dopamine Receptor Signaling Pathway Gamma-aminobutyric Acid Transport Saliva Secretion Bile Acid Secretion Microtubule Depolymerization Cellular Calcium Ion Homeostasis Neuron Differentiation Carboxylic Acid Transport Calcium Ion Homeostasis Organic Acid Transport Oligopeptide Transport Negative Regulation Of Sodium Ion Transport	Calcium Ion Transmembrane Transport Inositol Phosphate-mediated Signaling Calcium Ion Transport Metal Ion Transport Cellular Chemical Homeostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Cation Transport Cellular Homeostasis Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemical Homeostasis Cation Transmembrane Transport Ion Transport Cellular Ion Homeostasis Energy Reserve Metabolic Process Immune Response-regulating Signaling Pathway Second-messenger-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Immune Response Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Secretion Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Homeostatic Process Fc-epsilon Receptor Signaling Pathway Response To Stimulus Phagocytosis Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		allosteric ankyrin arises belongs branched channels detectors enthalpy evolved gating kcal macroscopic melastatin polymodal specialized subfamilies tetramers thermal trpa trpa1 trpm trpm8 trpv trpv1 trpv3 vanilloid voltage	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpa1 trpc1 trpc3 trpc5 trpm3 trpm4 trpm5 trpm6 trpm7 trpm8 trpml1 trpp2 trpv1 trpv2 trpv4 vertebral
Tagcloud (Difference) ?		allosteric ankyrin arises belongs branched channels detectors enthalpy evolved gating kcal macroscopic melastatin polymodal specialized subfamilies tetramers thermal trpa trpm trpv trpv3 vanilloid voltage	analyse anatomically convey drg drgs fibres ganglia ganglion refined somatosensation string trigeminal trpc1 trpc3 trpm3 trpm4 trpm5 trpm6 trpm7 trpml1 trpp2 trpv2 trpv4 vertebral
Tagcloud (Intersection) ?		trpa1 trpc5 trpm8 trpv1