TRPC5 and TRPC4

Number of citations of the paper that reports this interaction (PubMedID 12032305)
37

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vitro, in vivo)

		TRPC5	TRPC4
Description		transient receptor potential cation channel subfamily C member 5	transient receptor potential cation channel subfamily C member 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Presynapse	Plasma Membrane Caveola Cell-cell Junction Cell Surface Membrane Basolateral Plasma Membrane Cortical Cytoskeleton Protein-containing Complex Cation Channel Complex Calcium Channel Complex Membrane Raft
	Molecular Function	Actin Binding Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Secretion Monoatomic Ion Transmembrane Transport Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		TRP channels Role of second messengers in netrin-1 signaling	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Smoking behavior ( 19247474)	Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		9 interacting genes: DRD2 ENKUR ITPR3 MX1 NHERF1 STMN2 STMN3 TRPC1 TRPC4	10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 NHERF1 TJP1 TRPC1 TRPC5
Entrez ID		7224	7223
HPRD ID		02273	09154
Ensembl ID		ENSG00000072315	ENSG00000133107
Uniprot IDs		Q9UL62	Q9UBN4
PDB IDs		6YSN 7D4P 7D4Q 7E4T 7WDB 7X6C 7X6I 8GVW 8GVX	8WPL 8WPM 8WPN
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Acid Secretion Inorganic Ion Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Calcium Ion Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Metal Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Gamma-aminobutyric Acid Transport Monoatomic Cation Transport Cation Channel Complex Microtubule Depolymerization Regulation Of Sequestering Of Calcium Ion Chemical Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Ion Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Intracellular Chemical Homeostasis Protein Depolymerization Microtubule Polymerization Or Depolymerization Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Cellular Homeostasis Carboxylic Acid Transport Organic Acid Transport Homeostatic Process Inorganic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Structural Constituent Of Presynaptic Actin Cytoskeleton Renal Phosphate Ion Absorption Tubulin Binding Monoatomic Ion Transmembrane Transport Regulation Of Sodium Ion Transport Response To Metal Ion Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Organic Anion Transport Regulation Of Metal Ion Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Phenol-containing Compound Metabolic Process Apical Part Of Cell	Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Ion Transmembrane Transport Calcium Channel Activity Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Metal Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Monoatomic Ion Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Cation Transport Inorganic Ion Homeostasis Calcium Ion Homeostasis Monoatomic Ion Transport Calcium Ion Transmembrane Import Into Cytosol Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Homeostatic Process Monoatomic Ion Transmembrane Transport Plasma Membrane Chemical Homeostasis Intracellular Calcium Ion Homeostasis Transport Vesicle Membrane Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Intracellular Chemical Homeostasis Sarcoplasmic Reticulum Phospholipase C-activating Dopamine Receptor Signaling Pathway Store-operated Calcium Channel Activity Apical Part Of Cell Cellular Homeostasis Calcium Ion Transmembrane Transporter Activity Secretory Granule Membrane Phosphatidylinositol Binding Cellular Response To Ethanol G Protein-coupled Receptor Signaling Pathway Cation Channel Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Membrane Acid Secretion Calcium-mediated Signaling Receptor Complex
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