MX1 and CAB39L

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MX1	CAB39L
Description		MX dynamin like GTPase 1	calcium binding protein 39 like
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse	Cytoplasm Cytosol Serine/threonine Protein Kinase Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response	Intracellular Signal Transduction
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	Energy dependent regulation of mTOR by LKB1-AMPK
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 32439900)
Interacting Genes		42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623	4 interacting genes: CFTR MLH1 MX1 SCML2
Entrez ID		4599	81617
HPRD ID		00919	12993
Ensembl ID		ENSG00000157601	ENSG00000102547
Uniprot IDs		H9KVC7 P20591	Q86WE6 Q9H9S4
PDB IDs		3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM	3ZHP
Enriched GO Terms of Interacting Partners?		Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Isotype Switching To IgA Isotypes RNA Catabolic Process Guanine/thymine Mispair Binding MutSalpha Complex Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Regulation Of Mitotic Recombination Meiotic Telomere Clustering Mismatch Repair Complex Negative Regulation Of Mitotic Recombination Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Interleukin-27-mediated Signaling Pathway Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance U4 SnRNA 3'-end Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process Amelogenesis Telomere Localization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Mismatched DNA Binding
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