MX1 and HMGXB4

Number of citations of the paper that reports this interaction (PubMedID 25447205)
0

Data Source:
BioGRID (two hybrid)

		MX1	HMGXB4
Description		MX dynamin like GTPase 1	HMG-box containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse	Nucleus NURF Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response	Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623	24 interacting genes: AKAP17A CREBBP EPM2A H3-4 HABP4 INO80B JMJD6 LENG8 MX1 NKAPD1 NR1H2 PIAS2 SRPK2 STAC3 STRBP SUMO2 TENT5B TNNT1 TSC22D1 TSPYL2 UBE2I UBL5 UROD ZCCHC10
Entrez ID		4599	10042
HPRD ID		00919	05267
Ensembl ID		ENSG00000157601	ENSG00000100281
Uniprot IDs		H9KVC7 P20591	Q7Z641 Q9UGU5
PDB IDs		3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?		Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing	SUMO Transferase Activity Protein Sumoylation Protein Tag Activity Regulation Of RNA Splicing RNA Splicing MRNA Metabolic Process Nuclear Body Organization Nucleus Chromatin Remodeling Nucleic Acid Metabolic Process PML Body MRNA Processing Voltage-gated Calcium Channel Complex Nucleoplasm Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Binding Presynaptic Cytosol Postsynaptic Cytosol RNA Metabolic Process Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Contraction SUMO Conjugating Enzyme Activity Positive Regulation Of Secretion Of Lysosomal Enzymes Uroporphyrinogen Decarboxylase Activity Carbohydrate Phosphatase Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Chromatin Organization
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