MX1 and TRPC6

Number of citations: 0 (PubMedID 15757897)
Data Source: HPRD (in vitro, in vivo)

		MX1	TRPC6
Name		MX dynamin like GTPase 1	transient receptor potential cation channel subfamily C member 6
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse	Cytoplasm Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding	Actin Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response	Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Diseases		None	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		No GWAS studies recorded	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429 ) Daytime nap ( 33568662 ) DHEAS levels ( 34748635 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) General risk tolerance (MTAG) ( 30643258 ) Lung adenocarcinoma ( 28604730 ) Menarche (age at onset) ( 25231870 ) Monocyte count ( 32888494 ) Plateletcrit ( 32888494 ) Severity of nausea and vomiting of pregnancy ( 29563502 ) White blood cell count ( 32888494 )
Novel Interactors		13 novel interactors: CCL16 CD5 DCP2 GGPS1 GPC4 MX2 NDC80 NDUFV3 PDE9A PGRMC1 PRDX6 PSG9 ZFP36	None recorded
Interacting Genes		42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623	9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		4599	7225
HPRD ID		00919	04710
Ensembl ID		ENSG00000157601	ENSG00000137672
Uniprot IDs		H9KVC7 P20591	Q9Y210
PDB IDs		3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM	5YX9 6UZ8 6UZA 7A6U 7DXF 7DXG
GO Terms Enriched among Interactors		Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing	Calcium Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Calcium Ion Transmembrane Transport Inositol 1,4,5 Trisphosphate Binding Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Channel Activity Monoatomic Ion Transport Cellular Response To Hydrogen Peroxide Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Intracellularly Gated Calcium Channel Activity Inorganic Ion Transmembrane Transport Phospholipase Activator Activity Response To Hydrogen Peroxide Manganese Ion Transport Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Cation Channel Complex Response To Calcium Ion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Response To Reactive Oxygen Species Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Calcium-mediated Signaling Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Transmembrane Transport Membrane Raft Plasma Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Calcium Ion Homeostasis Calcium Ion Import Regulation Of Calcium Ion Transport Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Homeostatic Process Membrane T Cell Costimulation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Perinuclear Region Of Cytoplasm Peptidyl-tyrosine Phosphorylation