GNA11

Description		G protein subunit alpha 11
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Regulation Of Blood Pressure Entrainment Of Circadian Clock Positive Regulation Of Insulin Secretion Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH Endothelin Receptor Signaling Pathway Cranial Skeletal System Development Ligand-gated Ion Channel Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Asthma ( 31959851)
Interacting Genes		17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A NHERF1 PTGIR RGS14 RGS3 TBXA2R TRPC3 TSHR
Entrez ID		2767
HPRD ID		00759
Ensembl ID		ENSG00000088256
Uniprot IDs		P29992
PDB IDs		6OIJ 7RKF 7TRY 7XXH
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Smooth Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Vascular Process In Circulatory System Circulatory System Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Signal Transduction Vasoconstriction Plasma Membrane Muscle Contraction Regulation Of Blood Circulation Muscle System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Inorganic Ion Homeostasis Membrane System Process Regulation Of Vasoconstriction Vascular Associated Smooth Muscle Contraction Regulation Of Cell Communication Regulation Of Signaling Endothelin Receptor Activity Calcium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of MAPK Cascade Calcium Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Intracellular Signal Transduction Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Renal Albumin Absorption G Protein-coupled Serotonin Receptor Complex Regulation Of ERK1 And ERK2 Cascade Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Type 1 Angiotensin Receptor Binding Chemical Homeostasis Renal Absorption
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