GNA11 and EDNRB

Number of citations of the paper that reports this interaction (PMID 10789830)
3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GNA11	EDNRB
Gene Name		guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	endothelin receptor type B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Heart Development Blood Coagulation Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Bosentan Sitaxentan
Diseases
GWAS			Hair color ( 23548203) Total ventricular volume ( 21116278)
Protein-Protein Interactions		17 interactors: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR	7 interactors: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3
Entrez ID		2767	1910
HPRD ID		00759	08834
Ensembl ID			ENSG00000136160
Uniprot IDs		P29992	P24530
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Vasoconstriction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Blood Circulation Cytosolic Calcium Ion Homeostasis Ion Homeostasis Chemical Homeostasis Regulation Of MAPK Cascade Regulation Of Phosphorylation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Homeostatic Process Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Phosphorylation Signal Transduction Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Cellular Chemical Homeostasis Signaling Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Cellular Metal Ion Homeostasis Cellular Homeostasis Cellular Cation Homeostasis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Ion Homeostasis Vascular Smooth Muscle Contraction Regulation Of Blood Pressure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Abiotic Stimulus Regulation Of Signal Transduction Muscle Contraction Regulation Of CAMP Biosynthetic Process Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Response To Stimulus Endothelin Receptor Signaling Pathway	Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Contraction Vasoconstriction Regulation Of Body Fluid Levels Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Potassium Ion Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Regulation Of Oxidoreductase Activity Angiogenesis Regulation Of The Force Of Heart Contraction By Chemical Signal Cardiovascular System Development Regulation Of Systemic Arterial Blood Pressure Regulation Of Blood Coagulation Cellular Metal Ion Homeostasis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Reactive Oxygen Species Metabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Wound Healing Vascular Smooth Muscle Contraction Blood Vessel Development Second-messenger-mediated Signaling Cellular Chemical Homeostasis Vasculature Development Ion Homeostasis Inositol Phosphate-mediated Signaling Wound Healing Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Ion Transport Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Regulation Of Developmental Pigmentation Positive Regulation Of Ion Transport Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Movement Cellular Homeostasis Response To Wounding Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Heart Contraction
Tagcloud ?		amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?