GNA11 and ADRA1B

Number of citations: 0 (PubMedID 9481484)
Data Source: HPRD (in vivo)

		GNA11	ADRA1B
Name		G protein subunit alpha 11	adrenoceptor alpha 1B
Structure			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Caveola Membrane Nuclear Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Regulation Of Blood Pressure Entrainment Of Circadian Clock Positive Regulation Of Insulin Secretion Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH Endothelin Receptor Signaling Pathway Cranial Skeletal System Development Ligand-gated Ion Channel Signaling Pathway	Regulation Of Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Regulation Of Vasoconstriction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Neuron-glial Cell Signaling
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs		None	Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Modafinil Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Mephentermine Methotrimeprazine Dextroamphetamine Dextroamphetamine Phendimetrazine Periciazine Acepromazine Thioproperazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Tetryzoline Perospirone Brexpiprazole Dosulepin Viloxazine Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
GWAS		Asthma ( 31959851 )	Diastolic blood pressure ( 27841878 ) Plasma anti-thyroglobulin levels ( 29678681 ) Psoriatic arthritis ( 26626624 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 )
Interacting Genes		17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A NHERF1 PTGIR RGS14 RGS3 TBXA2R TRPC3 TSHR	11 interacting genes: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1
Entrez ID		2767	147
HPRD ID		00759	00080
Ensembl ID		ENSG00000088256	ENSG00000170214
Uniprot IDs		P29992	P35368
PDB IDs		6OIJ 7RKF 7TRY 7XXH	Not available
GO Terms Enriched among Interactors		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Smooth Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Vascular Process In Circulatory System Circulatory System Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Signal Transduction Vasoconstriction Plasma Membrane Muscle Contraction Regulation Of Blood Circulation Muscle System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Inorganic Ion Homeostasis Membrane System Process Regulation Of Vasoconstriction Vascular Associated Smooth Muscle Contraction Regulation Of Cell Communication Regulation Of Signaling Endothelin Receptor Activity Calcium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of MAPK Cascade Calcium Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Intracellular Signal Transduction Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Renal Albumin Absorption G Protein-coupled Serotonin Receptor Complex Regulation Of ERK1 And ERK2 Cascade Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Type 1 Angiotensin Receptor Binding Chemical Homeostasis Renal Absorption	Response To Hormone Phototransduction System Process Receptor Internalization G Protein-coupled Receptor Binding Phospholipase C-activating Serotonin Receptor Signaling Pathway Detection Of Light Stimulus Photoreceptor Outer Segment Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Phototransduction, Visible Light Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Guanyl Nucleotide Binding Detection Of Abiotic Stimulus G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Binding Positive Regulation Of Transport G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Filopodium Assembly Signal Transduction Regulation Of The Force Of Heart Contraction Regulation Of Protein Localization To Cell Periphery Disordered Domain Specific Binding Positive Regulation Of Protein Localization Detection Of Visible Light Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To PH Response To Prostaglandin E Entrainment Of Circadian Clock Enzyme Regulator Activity Regulation Of Protein Localization Regulation Of Blood Pressure Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Plasma Membrane Heterotrimeric G-protein Complex Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Localization Actin Filament Binding Response To PH Blood Circulation Response To Ketone Acetylcholine Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway