GNA11 and TSHR

Number of citations of the paper that reports this interaction (PMID 8552586)
25

Data Source:
HPRD (in vivo)

		GNA11	TSHR
Gene Name		guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	thyroid stimulating hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Thyroid-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Heart Development Blood Coagulation Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Thyrotropin Alfa
Diseases
GWAS			Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		17 interactors: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR	24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC
Entrez ID		2767	7253
HPRD ID		00759	04537
Ensembl ID			ENSG00000165409
Uniprot IDs		P29992	F5GYU5 P16473
PDB IDs			1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Vasoconstriction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Blood Circulation Cytosolic Calcium Ion Homeostasis Ion Homeostasis Chemical Homeostasis Regulation Of MAPK Cascade Regulation Of Phosphorylation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Homeostatic Process Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Phosphorylation Signal Transduction Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Cellular Chemical Homeostasis Signaling Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Cellular Metal Ion Homeostasis Cellular Homeostasis Cellular Cation Homeostasis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Ion Homeostasis Vascular Smooth Muscle Contraction Regulation Of Blood Pressure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Abiotic Stimulus Regulation Of Signal Transduction Muscle Contraction Regulation Of CAMP Biosynthetic Process Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Response To Stimulus Endothelin Receptor Signaling Pathway	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance
Tagcloud ?		amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Difference) ?		amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Intersection) ?