TRAF1 and HGS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRAF1	HGS
Description		TNF receptor associated factor 1	hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Lysosome Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Extracellular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Population Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Transport Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Receptor Internalization Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Localization To Membrane Membrane Fission Positive Regulation Of Exosomal Secretion
Pathways		Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway	EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle
Drugs			Citric acid
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 24782177 23143596 30891314 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) White blood cell count ( 32888494)	Eye color traits ( 20463881) Refractive error ( 32231278)
Interacting Genes		244 interacting genes: A1CF ABHD17A ACTN3 AIRIM AKAP17A AQP1 ARID5A ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf216 CARHSP1 CASP10 CASP3 CASP6 CASP8 CATSPERT CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCDC198 CCHCR1 CD40 CDCA3 CDK18 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRACR2A CRY2 CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 DUSP13B DUSP21 DUSP4 EBF2 EDAR EHHADH ENKD1 EWSR1 FAM161A FAM161B FAM86C1P FBF1 FBXL18 FOSL2 GADD45GIP1 GATA1 GATA2 GATAD2B GCA GCM2 GEM GFI1B GIT2 GLIS3 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HELT HEY2 HGS HIVEP3 HMG20B HNRNPM HOXA1 HOXB5 HOXC8 HOXD12 IKBKB JOSD1 KANK2 KIAA1217 KIF1A KLHL38 KPNA2 KRT3 KRT75 LCOR LIN37 LMNTD2 LNX1 LNX2 LRRN1 LTBR MACIR MAP3K14 MAP6 MAPRE2 MATR3 METTL17 MORN3 MOS MSGN1 MYEF2 MYOZ1 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PATZ1 PBX3 PDE4D PHF21A PIN1 PITX1 PITX2 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RCOR3 RIIAD1 RIPK1 RIPK2 RIPOR3 RIPPLY1 RNF31 RTP5 SAMD11 SAXO4 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHC3 SHFL SIK3 SLC25A48 SLC25A6 SNRNP25 SNW1 SOHLH1 SPATA46 SPG21 SPMIP2 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TBC1D8 TBX18 TCEA2 TCF7L2 TCL1A TEAD4 TFAP2D TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSHZ2 TSSC4 USP2 USP7 UTP14C VEZF1 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZIC1 ZNF124 ZNF20 ZNF23 ZNF250 ZNF417 ZNF440 ZNF490 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF627 ZNF648 ZNF662 ZNF669 ZNF688 ZNF697 ZNF844	328 interacting genes: ABI2 ACLY ACOT11 ACTN3 ADRA2C AHCYL1 AKAP8L ANKRD55 ANTKMT APC APLP2 APP ARFIP2 ARL6IP1 ARMC7 ASB12 ATN1 ATP1A1 ATP2A2 ATXN1L BBC3 BCAS2 BEGAIN BFSP2 BICRAL BLOC1S1 BORCS6 BRINP3 BSG C1orf94 C20orf173 C3orf36 CASK CBS CCDC136 CCDC196 CCDC33 CCND3 CDR2 CDSN CEACAM6 CEP55 CEP57L1 CEP63 CEP68 CFAP68 CIMIP2A CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL CYB5R2 DAAM2 DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAAF19 DSN1 DTX2 DYDC1 EFHC2 EGFL7 EGFR EHMT2 EIF3F EPS15 ESRRG EXOC3L1 EXOC5 EXOC7 EXOC8 EYA2 FAM168A FAM185A FANCG FBN1 FCHSD2 FIGN FLOT1 FLOT2 FNDC11 FOXD4L1 FOXI1 FSD2 FTCD GATC GFAP GFI1B GGA2 GKAP1 GOLGA2 GOLGA6L9 GOLGA7B GUCA1C HAP1 HAUS1 HNRNPDL HNRNPM HSF4 HSFY1 HSPA8 ICA1L IFNA16 IFT74 IL2RB IL4R ILKAP ING5 INTS4 IPO4 JAKMIP2 JMJD7 KIAA0753 KIAA0825 KLF4 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT3 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT6A KRT75 KRT76 KRT82 KRT86 KRTAP19-5 KRTAP26-1 KRTAP7-1 LASP1 LDOC1 LINC00265 LITAF LMO1 LMO4 LRRC61 LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED21 MED22 MED25 MED30 MED4 MED7 MEIS3 MEST MET METTL27 MIF4GD MKNK1 MKRN3 MRFAP1L1 MTHFD1L NADSYN1 NDC80 NDUFB10 NEDD4 NEDD8 NEFL NF2 NFYC NMI NPAS2 NUP54 NUP62 NUTM2F ODAM OIP5 OSBPL5 P4HA3 PAK1 PAX5 PAX6 PEF1 PELP1 PFKM PIK3R1 PITX1 PKNOX2 PLA2G10 PLAAT1 PLCD1 PLD3 PLEKHB2 PMEPA1 PNMA1 POGZ POU2AF1 POU6F2 PPP1R16A PPP1R7 PPP2R3B PRR22 PRR5 PSMB11 PSMB4 PTCD3 RASSF4 RBCK1 RFC2 RFX6 RHOBTB3 RINT1 RNF4 RPRD1A RPS3A RSPO4 RSU1 RUNX1 SAPCD1 SAXO4 SCAMP3 SCRN1 SCT SDS SERGEF SERTAD3 SF3B3 SHANK3 SMAD2 SMAD3 SMAD5 SMARCB1 SNAP25 SNX1 SNX5 SNX7 SORBS3 SPATA12 SPC25 SPIRE2 SPMIP6 SS18L1 STAM STAM2 STK32C STMN3 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TBX19 TCP11L2 TEKT1 TEKT5 TFG TIMM10B TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TP53BP1 TRAF1 TRAF4 TRAK1 TRAP1 TRIM10 TRIM17 TRIM23 TRIM27 TRIM54 TRIM69 TRIM73 TRIML2 TSC1 TSG101 TUBB TUBB2A UBA1 UBA52 UBAP2 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 UBQLNL UBXN11 USHBP1 USP54 VGLL3 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 WASHC1 WWP2 YPEL3 ZNF302 ZNF34 ZNF430 ZNF44
Entrez ID		7185	9146
HPRD ID		03418	05085
Ensembl ID		ENSG00000056558	ENSG00000185359
Uniprot IDs		Q13077	A0A0S2Z4R4 O14964
PDB IDs		3M0D 5E1T 5H10	2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Activity Zinc Ion Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Non-canonical NF-kappaB Signal Transduction Nucleus DNA Binding Ripoptosome CD40 Receptor Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Necroptotic Process Death-inducing Signaling Complex Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Signaling Pathway Positive Regulation Of Programmed Cell Death Cytokine-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Identical Protein Binding Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Protein Linear Polyubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Death Receptor Binding	Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Protein Binding Structural Molecule Activity Organelle Organization Epithelial Cell Differentiation Supramolecular Fiber Organization Cytoskeleton Organization Cytoskeleton Morphogenesis Of An Epithelium Tissue Morphogenesis Anatomical Structure Morphogenesis Cellular Localization Cytosol Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin Protein Ligase Binding Intracellular Transport Intracellular Protein Localization Establishment Of Protein Localization Axonemal A Tubule Inner Sheath Microtubule-based Process Protein Transport Establishment Of Protein Localization To Vacuole Structural Constituent Of Cytoskeleton Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Establishment Of Localization In Cell Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT I Complex Protein Localization To Vacuole Multivesicular Body Assembly Multivesicular Body Organization Endosomal Transport Endosome Membrane Multivesicular Body Sorting Pathway Identical Protein Binding Epidermis Development Modification-dependent Protein Catabolic Process Late Endosome To Vacuole Transport Viral Budding Protein Tag Activity Core Mediator Complex Exocyst Organelle Localization
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