TRAF1 and BCL6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TRAF1	BCL6
Gene Name		TNF receptor-associated factor 1	B-cell CLL/lymphoma 6
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Replication Fork
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Complex Assembly Apoptotic Process Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Regulation Of Rho GTPase Activity Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Positive Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842 19503088)	B cell non-Hodgkin lymphoma ( 23749188) PR interval ( 23534349) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		164 interactors: A1CF ACTN3 AES AKAP17A ALS2CR11 AQP1 ARNT2 ARSJ BARD1 BCL6 BEX2 BIRC2 BIRC3 C14orf105 C19orf66 C1orf109 C1orf216 C5orf30 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 ECH1 EDAR EHHADH EWSR1 FAM161A FAM86C1 FBF1 FBXL18 FOSL2 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL1P1 GNG5 GORASP2 HAUS1 HEY2 HIVEP3 HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LOC149950 LTBR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NGFRAP1 NUFIP2 NUPL1 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 THAP7 TICAM1 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662	44 interactors: AES BCL11A BCL6B BCOR BLZF1 CDK19 CDK8 CHD3 CREBBP CUTC EP300 FBXO11 HDAC4 HDAC5 HDAC7 HDAC9 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MED17 MED6 MTA3 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 TRAF1 WNK4 ZBTB16 ZBTB7A ZBTB7B
Entrez ID		7185	604
HPRD ID		03418	00180
Ensembl ID		ENSG00000056558	ENSG00000113916
Uniprot IDs		Q13077	B5B0A5 P41182
PDB IDs		3M0D	1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ
Enriched GO Terms of Interacting Partners?		Cell Death Death Programmed Cell Death Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Positive Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cellular Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Necroptotic Process Regulation Of Transcription, DNA-templated Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Cell Communication Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Modification Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Hemopoiesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Immune System Development Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Immune System Process DNA-templated Transcription, Initiation Response To Organic Substance Leukocyte Differentiation Chromatin Modification Cellular Protein Modification Process Developmental Process Nitrogen Compound Metabolic Process Organ Development Chromosome Organization
Tagcloud ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?