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TRAF1 and BCL6
Number of citations of the paper that reports this interaction (PubMedID
27107012
)
72
Data Source:
BioGRID
(two hybrid, two hybrid)
TRAF1
BCL6
Description
TNF receptor associated factor 1
BCL6 transcription repressor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Golgi Apparatus
Paraspeckles
Molecular Function
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Apoptotic Process
Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Cytokine Production
Negative Regulation Of Cell-matrix Adhesion
Plasma Cell Differentiation
Immune System Process
Germinal Center Formation
Regulation Of Germinal Center Formation
Regulation Of Immune System Process
Negative Regulation Of Type 2 Immune Response
Negative Regulation Of B Cell Apoptotic Process
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Inflammatory Response
DNA Damage Response
Cell-matrix Adhesion
Rho Protein Signal Transduction
Spermatogenesis
Intracellular Protein Localization
Cell Population Proliferation
Pyramidal Neuron Differentiation
Actin Cytoskeleton Organization
B Cell Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Heterochromatin Formation
Negative Regulation Of Mast Cell Cytokine Production
Mononuclear Cell Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Rho Protein Signal Transduction
Type 2 Immune Response
B Cell Proliferation
Regulation Of Cell Population Proliferation
Regulation Of T Cell Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Memory T Cell Differentiation
T-helper 2 Cell Differentiation
Regulation Of T Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Differentiation
Negative Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Isotype Switching To IgE Isotypes
Negative Regulation Of Isotype Switching To IgE Isotypes
Erythrocyte Development
Cell Motility
Regulation Of Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Lymphocyte Activation
Negative Regulation Of Plasma Cell Differentiation
Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Mitotic Cell Cycle DNA Replication
Positive Regulation Of Cell Motility
Negative Regulation Of Cellular Senescence
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
FOXO-mediated transcription of cell death genes
Drugs
Diseases
Hairy-cell leukemia
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Rheumatoid arthritis (
24390342
24782177
23143596
30891314
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
White blood cell count (
32888494
)
Adverse response to drug (
30420678
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Allergic sensitization (
23817571
)
Appendicular lean mass (
33097823
)
Asthma (
31959851
)
B cell non-Hodgkin lymphoma (
23749188
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Blood urea nitrogen levels (
29403010
)
Glucose homeostasis traits (
25524916
)
Granulocyte percentage of myeloid white cells (
27863252
)
Height (
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
PR interval (
23534349
)
Pulmonary function (smoking interaction) (
23284291
)
Renal function-related traits (BUN) (
22797727
)
Selective IgA deficiency (
27723758
)
Self-reported allergy (
23817569
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
25760438
)
Interacting Genes
244 interacting genes:
A1CF
ABHD17A
ACTN3
AIRIM
AKAP17A
AQP1
ARID5A
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf216
CARHSP1
CASP10
CASP3
CASP6
CASP8
CATSPERT
CCDC116
CCDC120
CCDC146
CCDC185
CCDC187
CCDC198
CCHCR1
CD40
CDCA3
CDK18
CDKN1A
CDKN2B
CFLAR
CHCHD3
COX5B
CRACR2A
CRY2
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
DUSP13B
DUSP21
DUSP4
EBF2
EDAR
EHHADH
ENKD1
EWSR1
FAM161A
FAM161B
FAM86C1P
FBF1
FBXL18
FOSL2
GADD45GIP1
GATA1
GATA2
GATAD2B
GCA
GCM2
GEM
GFI1B
GIT2
GLIS3
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HELT
HEY2
HGS
HIVEP3
HMG20B
HNRNPM
HOXA1
HOXB5
HOXC8
HOXD12
IKBKB
JOSD1
KANK2
KIAA1217
KIF1A
KLHL38
KPNA2
KRT3
KRT75
LCOR
LIN37
LMNTD2
LNX1
LNX2
LRRN1
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
MATR3
METTL17
MORN3
MOS
MSGN1
MYEF2
MYOZ1
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PATZ1
PBX3
PDE4D
PHF21A
PIN1
PITX1
PITX2
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RCOR3
RIIAD1
RIPK1
RIPK2
RIPOR3
RIPPLY1
RNF31
RTP5
SAMD11
SAXO4
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHC3
SHFL
SIK3
SLC25A48
SLC25A6
SNRNP25
SNW1
SOHLH1
SPATA46
SPG21
SPMIP2
SPOP
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TBC1D8
TBX18
TCEA2
TCF7L2
TCL1A
TEAD4
TFAP2D
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSHZ2
TSSC4
USP2
USP7
UTP14C
VEZF1
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZIC1
ZNF124
ZNF20
ZNF23
ZNF250
ZNF417
ZNF440
ZNF490
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF627
ZNF648
ZNF662
ZNF669
ZNF688
ZNF697
ZNF844
91 interacting genes:
ANKRD53
ARHGEF9
ARRDC3
ATP23
BCL11A
BCL6B
BCOR
BLZF1
CABP4
CDK19
CDK8
CFAP161
CFAP97D1
CHD3
CNOT2
CRBN
CREBBP
CTNNB1
CUTC
DVL2
ENO1
EP300
FBXO11
GATA1
GLRX3
GOLGA2
HDAC1
HDAC4
HDAC5
HDAC7
HDAC9
IHO1
IRF4
JUN
JUNB
JUND
KIFC3
KLHL12
KLHL20
KRTAP13-1
KRTAP13-2
KRTAP19-1
LIMS3
LIMS4
MAPK1
MDFI
MED17
MED6
MTA3
MTUS2
NCOR1
NCOR2
PAK1
PBX4
PELI1
PFDN5
PIN1
PML
POF1B
PPARD
PPTC7
PRKD3
PSMB4
RAF1
REL
RUNX1T1
SIAH1
SIN3A
SNCA
SP1
SPI1
SPMIP2
SPMIP4
SPMIP6
SSX2IP
TEKT4
TFIP11
TLE5
TP53
TP53BP1
TRAF1
TRAF2
TRIB3
TWIST1
WDR83
WNK4
ZBTB16
ZBTB17
ZBTB7A
ZBTB7B
ZNHIT1
Entrez ID
7185
604
HPRD ID
03418
00180
Ensembl ID
ENSG00000056558
ENSG00000113916
Uniprot IDs
Q13077
B5B0A5
P41182
PDB IDs
3M0D
5E1T
5H10
1R28
1R29
1R2B
2EN2
2EOS
2LCE
2YRM
3BIM
3E4U
3LBZ
4CP3
4U2M
5H7G
5H7H
5MW2
5MW6
5MWD
5N1X
5N1Z
5N20
5N21
5X4M
5X4N
5X4O
5X4P
5X4Q
5X9O
5X9P
6C3L
6C3N
6CQ1
6EW6
6EW7
6EW8
6TBT
6TCJ
6TOF
6TOG
6TOH
6TOI
6TOJ
6TOK
6TOL
6TOM
6TON
6TOO
6XMX
6XWF
6XXS
6XYX
6XZZ
6Y17
6ZBU
7BDE
7GUD
7GUE
7GUF
7GUG
7GUH
7GUI
7GUJ
7GUK
7GUL
7GUM
7GUN
7GUO
7GUP
7GUQ
7GUR
7GUS
7GUT
7GUU
7GUV
7GUW
7GUX
7GUY
7GUZ
7GV0
7GV1
7GV2
7GV3
7GV4
7GV5
7GV6
7GV7
7GV8
7GV9
7GVA
7GVB
7GVC
7GVD
7GVE
7GVF
7GVG
7GVH
7GVI
7GVJ
7GVK
7GVL
7GVM
7GVN
7GVO
7GVP
7GVQ
7GVR
7GVS
7GVT
7GVU
7GVV
7GVW
7GVX
7GVY
7GVZ
7GW0
7GW1
7GW2
7GW3
7GW4
7GW5
7GW6
7GW7
7GW8
7GW9
7GWA
7GWB
7GWC
7GWD
7GWE
7GWF
7GWG
7GWH
7GWI
7GWJ
7GWK
7GWL
7GWM
7GWN
7GWO
7GWP
7GWQ
7GWR
7GWS
7GWT
7GWU
7GWV
7GWW
7GWX
7GWY
7GWZ
7GX0
7GX1
7GX2
7GX3
7GX4
7GX5
7GX6
7GX7
7GX8
7GX9
7GXA
7GXB
7GXC
7GXD
7GXE
7GXF
7GXG
7GXH
7GXI
7GXJ
7GXK
7GXL
7GXM
7GXN
7GXO
7GXP
7GXQ
7GXR
7GXS
7GXT
7GXU
7GXV
7GXW
7GXX
7GXY
7GXZ
7GY0
7GY1
7GY2
7GY3
7LWE
7LWF
7LWG
7LZQ
7LZR
7LZS
7OKD
7OKE
7OKF
7OKG
7OKH
7OKI
7OKJ
7OKK
7OKL
7OKM
7Q7R
7Q7S
7Q7T
7Q7U
7Q7V
7QK0
7RUW
7RUX
7RUY
7RUZ
7RV0
7RV1
7RV2
7RV3
7RV4
7RV5
7RV6
7RV7
7RV8
7RV9
7T0S
7T0T
7T0U
7ZWN
7ZWO
7ZWP
7ZWQ
7ZWR
7ZWS
7ZWT
7ZWU
7ZWV
7ZWW
7ZWX
7ZWY
7ZWZ
8AS9
8C78
Enriched GO Terms of Interacting Partners
?
Tumor Necrosis Factor-mediated Signaling Pathway
Protein Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Tumor Necrosis Factor Receptor Activity
Zinc Ion Binding
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Non-canonical NF-kappaB Signal Transduction
Nucleus
DNA Binding
Ripoptosome
CD40 Receptor Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Necroptotic Process
Death-inducing Signaling Complex
Apoptotic Process
Regulation Of Programmed Cell Death
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Programmed Necrotic Cell Death
Programmed Cell Death
Cell Death
CD40 Signaling Pathway
Positive Regulation Of Programmed Cell Death
Cytokine-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Necroptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Programmed Necrotic Cell Death
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of RNA Metabolic Process
Identical Protein Binding
Apoptotic Signaling Pathway
Sequence-specific Double-stranded DNA Binding
Protein Linear Polyubiquitination
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Canonical NF-kappaB Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Death Receptor Binding
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Binding
Transcription Repressor Complex
DNA-binding Transcription Factor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Transcription Corepressor Activity
Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Intracellular Signal Transduction
Nucleoplasm
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Biosynthetic Process
Histone Deacetylase Activity, Hydrolytic Mechanism
Regulation Of Cell Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Chromatin Remodeling
Histone Deacetylase Complex
Regulation Of Macromolecule Metabolic Process
Regulation Of Developmental Process
Protein Lysine Deacetylase Activity
Transcription Corepressor Binding
Positive Regulation Of Metabolic Process
Transcription Coactivator Binding
Chromatin Organization
Negative Regulation Of Developmental Process
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