TRAF1 and TRPV6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TRAF1	TRPV6
Gene Name		TNF receptor-associated factor 1	transient receptor potential cation channel, subfamily V, member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Calcium Channel Activity Protein Binding Calmodulin Binding
	Biological Process	Protein Complex Assembly Apoptotic Process Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway	Calcium Ion Transport Regulation Of Calcium Ion-dependent Exocytosis Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways			Ion channel transport TRP channels Stimuli-sensing channels
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		164 interactors: A1CF ACTN3 AES AKAP17A ALS2CR11 AQP1 ARNT2 ARSJ BARD1 BCL6 BEX2 BIRC2 BIRC3 C14orf105 C19orf66 C1orf109 C1orf216 C5orf30 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 ECH1 EDAR EHHADH EWSR1 FAM161A FAM86C1 FBF1 FBXL18 FOSL2 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL1P1 GNG5 GORASP2 HAUS1 HEY2 HIVEP3 HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LOC149950 LTBR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NGFRAP1 NUFIP2 NUPL1 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 THAP7 TICAM1 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662	16 interactors: CALB1 CALM1 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 MDFI MID2 NEDD4 NOTCH2NL PDE9A PNMA1 PRKCA PTPN1 S100A10 TRAF1
Entrez ID		7185	55503
HPRD ID		03418	05982
Ensembl ID		ENSG00000056558	ENSG00000165125
Uniprot IDs		Q13077	Q9H1D0
PDB IDs		3M0D
Enriched GO Terms of Interacting Partners?		Cell Death Death Programmed Cell Death Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Positive Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cellular Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Necroptotic Process Regulation Of Transcription, DNA-templated Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Cell Communication Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Modification Process	Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Light Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response Negative Regulation Of Transport Cellular Response To Radiation Blood Coagulation Hemostasis Response To Stress Response To Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Regulation Of Intracellular Signal Transduction Rhodopsin Mediated Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lyase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Activation Activation Of Phospholipase C Activity Response To Wounding Defense Response Immune System Process Regulation Of Adenylate Cyclase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Protein Phosphorylation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Cyclase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of CAMP Metabolic Process Innate Immune Response Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Metanephric Connecting Tubule Development Positive Regulation Of Dense Core Granule Biogenesis Transmission Of Virus Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Development Involved In Symbiotic Interaction Response To Light Stimulus Positive Regulation Of Phospholipase Activity Phototransduction, Visible Light Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit	abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 ercc6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1
Tagcloud (Difference) ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit	abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 ercc6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1
Tagcloud (Intersection) ?