TRAF1 and TBC1D8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRAF1	TBC1D8
Description		TNF receptor associated factor 1	TBC1 domain family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Membrane
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway	System Process Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Cilium Assembly
Pathways		Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 24782177 23143596 30891314 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) White blood cell count ( 32888494)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive decline rate in late mild cognitive impairment ( 26252872) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Granulocyte count ( 27863252) Heel bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Osteoporosis-related phenotypes ( 20548944) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		244 interacting genes: A1CF ABHD17A ACTN3 AIRIM AKAP17A AQP1 ARID5A ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf216 CARHSP1 CASP10 CASP3 CASP6 CASP8 CATSPERT CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCDC198 CCHCR1 CD40 CDCA3 CDK18 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRACR2A CRY2 CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 DUSP13B DUSP21 DUSP4 EBF2 EDAR EHHADH ENKD1 EWSR1 FAM161A FAM161B FAM86C1P FBF1 FBXL18 FOSL2 GADD45GIP1 GATA1 GATA2 GATAD2B GCA GCM2 GEM GFI1B GIT2 GLIS3 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HELT HEY2 HGS HIVEP3 HMG20B HNRNPM HOXA1 HOXB5 HOXC8 HOXD12 IKBKB JOSD1 KANK2 KIAA1217 KIF1A KLHL38 KPNA2 KRT3 KRT75 LCOR LIN37 LMNTD2 LNX1 LNX2 LRRN1 LTBR MACIR MAP3K14 MAP6 MAPRE2 MATR3 METTL17 MORN3 MOS MSGN1 MYEF2 MYOZ1 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PATZ1 PBX3 PDE4D PHF21A PIN1 PITX1 PITX2 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RCOR3 RIIAD1 RIPK1 RIPK2 RIPOR3 RIPPLY1 RNF31 RTP5 SAMD11 SAXO4 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHC3 SHFL SIK3 SLC25A48 SLC25A6 SNRNP25 SNW1 SOHLH1 SPATA46 SPG21 SPMIP2 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TBC1D8 TBX18 TCEA2 TCF7L2 TCL1A TEAD4 TFAP2D TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSHZ2 TSSC4 USP2 USP7 UTP14C VEZF1 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZIC1 ZNF124 ZNF20 ZNF23 ZNF250 ZNF417 ZNF440 ZNF490 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF627 ZNF648 ZNF662 ZNF669 ZNF688 ZNF697 ZNF844	3 interacting genes: SPP1 TRAF1 TRAF4
Entrez ID		7185	11138
HPRD ID		03418	06752
Ensembl ID		ENSG00000056558	ENSG00000204634
Uniprot IDs		Q13077	J3KQ40 O95759
PDB IDs		3M0D 5E1T 5H10
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Activity Zinc Ion Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Non-canonical NF-kappaB Signal Transduction Nucleus DNA Binding Ripoptosome CD40 Receptor Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Necroptotic Process Death-inducing Signaling Complex Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Signaling Pathway Positive Regulation Of Programmed Cell Death Cytokine-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Identical Protein Binding Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Protein Linear Polyubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Death Receptor Binding	Thioesterase Binding Tumor Necrosis Factor Receptor Binding Signaling Adaptor Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Androgen Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Bone Resorption Response To Macrophage Colony-stimulating Factor Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Respiratory Tube Development Hormone Catabolic Process Regulation Of Collateral Sprouting Decidualization Regulation Of Neuron Projection Regeneration Perinuclear Region Of Cytoplasm Response To Vitamin D Regulation Of Axon Regeneration Small Molecule Binding Androgen Metabolic Process Steroid Catabolic Process Respiratory Gaseous Exchange By Respiratory System WW Domain Binding Extracellular Matrix Binding Regulation Of Bone Resorption
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