TRAF1 and TEAD4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TRAF1	TEAD4
Gene Name		TNF receptor-associated factor 1	TEA domain family member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Complex Assembly Apoptotic Process Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway	Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Muscle Organ Development Gene Expression Hippo Signaling
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842 19503088)	Narcolepsy with cataplexy ( 23496005)
Protein-Protein Interactions		164 interactors: A1CF ACTN3 AES AKAP17A ALS2CR11 AQP1 ARNT2 ARSJ BARD1 BCL6 BEX2 BIRC2 BIRC3 C14orf105 C19orf66 C1orf109 C1orf216 C5orf30 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 ECH1 EDAR EHHADH EWSR1 FAM161A FAM86C1 FBF1 FBXL18 FOSL2 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL1P1 GNG5 GORASP2 HAUS1 HEY2 HIVEP3 HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LOC149950 LTBR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NGFRAP1 NUFIP2 NUPL1 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 THAP7 TICAM1 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662	18 interactors: CCDC172 CCDC85B CCNDBP1 CEP55 CEP70 GOLGA2 KIAA0753 LZTS2 MYH7 PNMA1 RABGEF1 SSX2IP TRAF1 TRIM27 VGLL1 VPS52 WWTR1 YAP1
Entrez ID		7185	7004
HPRD ID		03418	03421
Ensembl ID		ENSG00000056558	ENSG00000197905
Uniprot IDs		Q13077	D3DUQ6 Q15561
PDB IDs		3M0D
Enriched GO Terms of Interacting Partners?		Cell Death Death Programmed Cell Death Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Positive Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cellular Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Necroptotic Process Regulation Of Transcription, DNA-templated Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Cell Communication Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Modification Process	Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Hippo Signaling Negative Regulation Of Protein Transport Negative Regulation Of Cytokine Secretion Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Kit Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Mitotic Cell Cycle Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Interleukin-2 Secretion Embryonic Ectodermal Digestive Tract Development Cell Cycle Regulation Of Protein Localization Negative Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Phosphorylation Cytokinesis Cell Division Negative Regulation Of Intracellular Transport Regulation Of Fat Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation Regulation Of Cytokine Secretion Regulation Of Epithelial Cell Differentiation Negative Regulation Of Calcium Ion Import Negative Regulation Of Mast Cell Activation Involved In Immune Response Intraciliary Transport Involved In Cilium Morphogenesis Ectodermal Cell Differentiation Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Secretion By Cell Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma Secretion Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Ubiquitination Negative Regulation Of Secretion Negative Regulation Of Signaling Regulation Of Signal Transduction Spindle Midzone Assembly Protein Modification By Small Protein Conjugation
Tagcloud ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit	amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap yap1
Tagcloud (Difference) ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit	amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap yap1
Tagcloud (Intersection) ?