TPR and MAD1L1

  • Number of citations: 90 (PubMedID 31588029)
  • Data Source: BioGRID (two hybrid, affinity chromatography technology)

TPR

MAD1L1

Name translocated promoter region, nuclear basket protein mitotic arrest deficient 1 like 1
Structure PDB 5TO5 PDB 1GO4
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Diseases None
GWAS No GWAS studies recorded
  • Adult body size ( 32376654 )
  • Adverse response to drug ( 30420678 )
  • Age at first birth ( 34211149 )
  • Age at first sexual intercourse ( 34211149 27089180 )
  • Alcohol consumption (drinks per week) ( 30643258 )
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 )
  • Anthropometric traits (multi-trait analysis) ( 30166351 )
  • Anxiety ( 31906708 )
  • Autism spectrum disorder or schizophrenia ( 28540026 )
  • Bipolar disorder ( 21926972 34002096 28115744 27329760 )
  • Bitter alcoholic beverage consumption ( 31046077 )
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 )
  • Coronary artery disease ( 29212778 33020668 )
  • Dimensional psychopathology (Social) ( 29496196 )
  • Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439 )
  • Gastroesophageal reflux disease ( 34187846 31527586 )
  • General factor of neuroticism ( 30867560 )
  • Gut microbiota relative abundance (Streptococcus) ( 33208821 )
  • Hand grip strength ( 29691431 )
  • Idiopathic pulmonary fibrosis ( 31710517 )
  • Longevity ( 20834067 )
  • Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 )
  • Myocardial infarction ( 33532862 )
  • Number of sexual partners ( 30643258 )
  • Platelet count ( 32888494 )
  • Plateletcrit ( 32888494 )
  • Prostate cancer ( 29892016 )
  • Prostate cancer (advanced) ( 29892016 )
  • Refractive error ( 32231278 )
  • Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )
  • Risk-taking tendency (4-domain principal component model) ( 30643258 )
  • Rosacea symptom severity ( 29771307 )
  • Schizophrenia ( 30285260 22688191 28991256 23974872 29483656 )
  • Schizophrenia or bipolar disorder ( 24280982 )
  • Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486 )
  • Sepsis (28-day mortality) ( 32592749 )
  • Sleep duration (short sleep) ( 30846698 )
  • Smoking initiation ( 33082346 )
  • Smoking status (ever vs never smokers) ( 30643258 )
  • Superior frontal gyrus volume ( 31530798 )
  • Superior temporal gyrus volume ( 31530798 )
  • Systolic blood pressure ( 30578418 )
  • Testicular germ cell tumor ( 28604732 23666239 28604728 )
  • Vaginal microbiome composition (Shannon diversity index) ( 32723796 )
Novel Interactors 1 novel interactors: TNFSF4 15 novel interactors: AIMP2 ANXA5 CCND2 CHERP CHST12 FSCN1 HOXA10 NXPH1 PIN4 PRKAR1B RPA3 S100P STAM TTYH3 TULP4
Interacting Genes 19 interacting genes: APC CDK1 ERCC6 HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 MECOM NUP153 NUP98 PRKACA SHC1 SUMO2 USP7 WEE2-AS1 YWHAQ ZC3HC1 63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID 7175 8379
HPRD ID 08927 04065
Ensembl ID ENSG00000047410 ENSG00000002822
Uniprot IDs P12270 Q9Y6D9
PDB IDs 5TO5 5TO6 5TO7 5TVB 1GO4 4DZO 7B1F 7B1H 7B1J
GO Terms Enriched among Interactors