MAD1L1 and NXPH1

		MAD1L1	NXPH1
Description		mitotic arrest deficient 1 like 1	neurexophilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Extracellular Region Synaptic Cleft Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding Kinetochore Binding	Signaling Receptor Binding
	Biological Process	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint	Modulation Of Chemical Synaptic Transmission
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149 27089180) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 28115744 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604732 23666239 28604728) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain imaging ( 20100581) Femur bone mineral density x serum urate levels interaction ( 34046847) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Neuroticism ( 18762592) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Response to fenofibrate ( 22890011) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Waist-to-hip ratio adjusted for body mass index ( 27195708) Working memory ( 31598132)
Interacting Genes		63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32	1 interacting genes: NRXN1
Entrez ID		8379	30010
HPRD ID		04065	06867
Ensembl ID		ENSG00000002822	ENSG00000122584
Uniprot IDs		Q9Y6D9	P58417 Q3LID8
PDB IDs		1GO4 4DZO 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity	MAD1 Complex Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Deactivation Of Mitotic Spindle Assembly Checkpoint Kinetochore Binding Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Filopodium Assembly Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Positive Regulation Of Neuromuscular Synaptic Transmission Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding Postsynaptic Membrane Assembly Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Segregation Vocal Learning Postsynaptic Membrane Organization Positive Regulation Of Synapse Maturation Presynaptic Membrane Assembly Observational Learning Presynaptic Membrane Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Synaptic Vesicle Clustering Nuclear Pore Nuclear Basket Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Regulation Of Metaphase Plate Congression Auditory Behavior Negative Regulation Of Cellular Component Organization Neuron Cell-cell Adhesion Glutamatergic Neuron Differentiation Mechanosensory Behavior Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore
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