TPR and NUP153

Number of citations of the paper that reports this interaction (PMID 12802065)
50

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		TPR	NUP153
Gene Name		translocated promoter region, nuclear basket protein	nucleoporin 153kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Dynein Complex Extrinsic Component Of Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle	Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	Chromatin Binding MRNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Tubulin Binding Heat Shock Protein Binding Protein Homodimerization Activity Protein Anchor Poly(A) RNA Binding Mitogen-activated Protein Kinase Binding Dynein Complex Binding	DNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein Anchor
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Import Into Nucleus Mitotic Cell Cycle Carbohydrate Metabolic Process RNA Import Into Nucleus RNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Nuclear Pore Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Hexose Transport Pathogenesis Gene Expression Regulation Of MRNA Export From Nucleus Regulation Of Glucose Transport Regulation Of Mitotic Sister Chromatid Separation Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Positive Regulation Of Heterochromatin Assembly Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Small Molecule Metabolic Process Negative Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Cell Division Transmembrane Transport Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly	Mitotic Cell Cycle Carbohydrate Metabolic Process Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Protein Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Viral Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Transmembrane Transport Viral Penetration Into Host Nucleus
Pathways		Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport	Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport
Drugs
Diseases
GWAS			Height ( 18391951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: APC HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 NUP153 NUP98 SHC1 YWHAQ	24 interactors: APC BRCA1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 NFX1 NUP62 NUTF2 NXF1 NXF2 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-1 XPO1 XPO5 XPO7 XPOT
Entrez ID		7175	9972
HPRD ID		08927	04899
Ensembl ID		ENSG00000047410	ENSG00000124789
Uniprot IDs		P12270	B4DIK2 F6QR24 P49790 Q4LE47 Q7Z743
PDB IDs			2EBQ 2EBR 2EBV 2GQE
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Nuclear Import Mitotic Cell Cycle Cell Cycle Protein Localization To Nucleus Apoptotic Process Programmed Cell Death Cell Cycle Process Regulation Of Cellular Localization Signal Transduction Cell Death Death Nuclear Pore Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Pore Organization Positive Regulation Of Signal Transduction Response To UV-C Pore Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Establishment Of Protein Localization Protein Import Into Nucleus Regulation Of Protein Processing Cellular Response To Stimulus Regulation Of Catalytic Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Transport Activation Of MAPK Activity Response To Radiation Mitotic Cell Cycle Checkpoint Protein Import Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Protein Complex Assembly Protein Localization To Organelle Regulation Of Signal Transduction Response To Toxic Substance Mitotic Spindle Assembly Checkpoint Response To Abiotic Stimulus	Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Viral Process Nuclear Export Protein Transport Establishment Of Protein Localization Intracellular Transport RNA Transport Establishment Of Localization In Cell RNA Localization Protein Localization To Nucleus Intracellular Protein Transport Protein Localization Protein Import Into Nucleus Nuclear Import MRNA Transport Cellular Localization Protein Import Protein Export From Nucleus Transport Cellular Protein Localization Protein Localization To Organelle Establishment Of Protein Localization To Organelle Cellular Response To Organic Substance Protein Targeting Regulation Of Intracellular Transport Cell Cycle NLS-bearing Protein Import Into Nucleus Regulation Of Cytoskeleton Organization Gene Expression RNA Export From Nucleus Response To DsRNA Response To Organic Substance Cellular Response To Cytokine Stimulus MAPK Import Into Nucleus Viral Life Cycle Response To Growth Factor Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Intracellular Transport Of Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ribosomal Small Subunit Export From Nucleus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Localization Response To Epidermal Growth Factor Response To Cytokine Regulation Of Intracellular Protein Transport
Tagcloud ?		aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast	acted bona breakpoints chimeras deregulate fg fide functioned gly heterodimerization hox hoxa9 nih nucleoporin nucleoporins nup214 nup98 oncogenesis oncoproteins pbx phe physically recruit repeat repeats segments transactivation transactivators vp16
Tagcloud (Difference) ?		aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast	acted bona breakpoints chimeras deregulate fg fide functioned gly heterodimerization hox hoxa9 nih nucleoporin nucleoporins nup214 nup98 oncogenesis oncoproteins pbx phe physically recruit repeat repeats segments transactivation transactivators vp16
Tagcloud (Intersection) ?