TPR and NUP98

Number of citations of the paper that reports this interaction (PMID 11248057)
23

Data Source:
HPRD (in vivo)

		TPR	NUP98
Gene Name		translocated promoter region, nuclear basket protein	nucleoporin 98kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Dynein Complex Extrinsic Component Of Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	Chromatin Binding MRNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Tubulin Binding Heat Shock Protein Binding Protein Homodimerization Activity Protein Anchor Poly(A) RNA Binding Mitogen-activated Protein Kinase Binding Dynein Complex Binding	Transporter Activity Protein Binding Structural Constituent Of Nuclear Pore Peptide Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Import Into Nucleus Mitotic Cell Cycle Carbohydrate Metabolic Process RNA Import Into Nucleus RNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Nuclear Pore Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Hexose Transport Pathogenesis Gene Expression Regulation Of MRNA Export From Nucleus Regulation Of Glucose Transport Regulation Of Mitotic Sister Chromatid Separation Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Positive Regulation Of Heterochromatin Assembly Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Small Molecule Metabolic Process Negative Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Cell Division Transmembrane Transport Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly	Protein Import Into Nucleus, Docking Mitotic Cell Cycle Carbohydrate Metabolic Process DNA Replication Nucleocytoplasmic Transport Nuclear Pore Organization Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process MRNA Transport Nuclear Pore Complex Assembly Transmembrane Transport
Pathways		Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APC HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 NUP153 NUP98 SHC1 YWHAQ	18 interactors: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NFX1 NUP133 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR
Entrez ID		7175	4928
HPRD ID		08927	03012
Ensembl ID		ENSG00000047410	ENSG00000110713
Uniprot IDs		P12270	P52948
PDB IDs			1KO6 2Q5X 2Q5Y 3MMY
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Nuclear Import Mitotic Cell Cycle Cell Cycle Protein Localization To Nucleus Apoptotic Process Programmed Cell Death Cell Cycle Process Regulation Of Cellular Localization Signal Transduction Cell Death Death Nuclear Pore Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Pore Organization Positive Regulation Of Signal Transduction Response To UV-C Pore Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Establishment Of Protein Localization Protein Import Into Nucleus Regulation Of Protein Processing Cellular Response To Stimulus Regulation Of Catalytic Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Transport Activation Of MAPK Activity Response To Radiation Mitotic Cell Cycle Checkpoint Protein Import Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Protein Complex Assembly Protein Localization To Organelle Regulation Of Signal Transduction Response To Toxic Substance Mitotic Spindle Assembly Checkpoint Response To Abiotic Stimulus	Viral Process Mitotic Cell Cycle MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Localization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Cell Cycle Mitotic Cell Cycle Process Cytoplasmic Transport Nuclear Envelope Organization Glucose Transport Hexose Transport Viral Life Cycle Viral Transcription Regulation Of Glucose Transport Cell Cycle Process Nucleus Organization Intracellular Transport Carbohydrate Transport MRNA Export From Nucleus RNA Export From Nucleus Protein Transport Organelle Organization Establishment Of Protein Localization Establishment Of Localization In Cell Pathogenesis Cytokine-mediated Signaling Pathway Gene Expression Protein Import Into Nucleus Nuclear Import N-terminal Peptidyl-lysine Acetylation Nuclear Export Regulation Of Mitotic Nuclear Division RNA Biosynthetic Process Cellular Localization Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Protein Localization Mitotic Spindle Checkpoint Protein Import Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Protein Localization To Nucleus Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition
Tagcloud ?		aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast
Tagcloud (Difference) ?		aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast
Tagcloud (Intersection) ?