TPR and IFI16

Number of citations of the paper that reports this interaction (PMID 12513910)
0

Data Source:
HPRD (two hybrid, in vivo)

		TPR	IFI16
Gene Name		translocated promoter region, nuclear basket protein	interferon, gamma-inducible protein 16
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoplasmic Dynein Complex Extrinsic Component Of Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck
	Molecular Function	Chromatin Binding MRNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Tubulin Binding Heat Shock Protein Binding Protein Homodimerization Activity Protein Anchor Poly(A) RNA Binding Mitogen-activated Protein Kinase Binding Dynein Complex Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Import Into Nucleus Mitotic Cell Cycle Carbohydrate Metabolic Process RNA Import Into Nucleus RNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Nuclear Pore Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Hexose Transport Pathogenesis Gene Expression Regulation Of MRNA Export From Nucleus Regulation Of Glucose Transport Regulation Of Mitotic Sister Chromatid Separation Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Positive Regulation Of Heterochromatin Assembly Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Small Molecule Metabolic Process Negative Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus Nuclear Pore Complex Assembly Cell Division Transmembrane Transport Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Transcription, DNA-templated Autophagy Inflammatory Response Cell Proliferation Regulation Of Autophagy Hemopoiesis Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport	Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS			C-reactive protein ( 22939635) Celiac disease and Rheumatoid arthritis ( 21383967) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: APC HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 NUP153 NUP98 SHC1 YWHAQ	10 interactors: APP AR BRCA1 CSNK2A1 ID1 ID2 ID3 TP53 TP53BP1 TPR
Entrez ID		7175	3428
HPRD ID		08927	00969
Ensembl ID		ENSG00000047410	ENSG00000163565
Uniprot IDs		P12270	Q16666
PDB IDs			2OQ0 3B6Y 3RLN 3RLO 3RNU
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Nuclear Import Mitotic Cell Cycle Cell Cycle Protein Localization To Nucleus Apoptotic Process Programmed Cell Death Cell Cycle Process Regulation Of Cellular Localization Signal Transduction Cell Death Death Nuclear Pore Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Pore Organization Positive Regulation Of Signal Transduction Response To UV-C Pore Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Establishment Of Protein Localization Protein Import Into Nucleus Regulation Of Protein Processing Cellular Response To Stimulus Regulation Of Catalytic Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Transport Activation Of MAPK Activity Response To Radiation Mitotic Cell Cycle Checkpoint Protein Import Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Protein Complex Assembly Protein Localization To Organelle Regulation Of Signal Transduction Response To Toxic Substance Mitotic Spindle Assembly Checkpoint Response To Abiotic Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle RNA Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Regulation Of Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Ossification Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Chromosome Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?		aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast	bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53
Tagcloud (Difference) ?		aa antiproliferative antiviral coexpression comprised curiously dimerization dimers document example exerted highlight hybrid lambda mediator nonfunctional p58ipk perturb pkr repressor select span stranded subdomains tetratricopeptide unrecognized utilizing verified yeast	bound break chromatin cytoplasm damage dsb ectopic etoposide foci fractionation gammah2ax hcc hep3b hepatocellular huh ifnb l02 localization mumol null nutlin pifithrin pretreatment redistributed sensor smmc strand subcellular tp53
Tagcloud (Intersection) ?