MAD1L1 and CHST12

		MAD1L1	CHST12
Description		mitotic arrest deficient 1 like 1	carbohydrate sulfotransferase 12
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Identical Protein Binding Kinetochore Binding	Sulfotransferase Activity Transferase Activity Chondroitin 4-sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint	Carbohydrate Biosynthetic Process Proteoglycan Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	CS-GAG biosynthesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149 27089180) Alcohol consumption (drinks per week) ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety ( 31906708) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 34002096 28115744 27329760) Bitter alcoholic beverage consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 33020668) Dimensional psychopathology (Social) ( 29496196) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Gut microbiota relative abundance (Streptococcus) ( 33208821) Hand grip strength ( 29691431) Idiopathic pulmonary fibrosis ( 31710517) Longevity ( 20834067) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myocardial infarction ( 33532862) Number of sexual partners ( 30643258) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656) Schizophrenia or bipolar disorder ( 24280982) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Sepsis (28-day mortality) ( 32592749) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Superior frontal gyrus volume ( 31530798) Superior temporal gyrus volume ( 31530798) Systolic blood pressure ( 30578418) Testicular germ cell tumor ( 28604732 23666239 28604728) Vaginal microbiome composition (Shannon diversity index) ( 32723796)	Blood protein levels ( 30072576) Diastolic blood pressure ( 27618452 27841878 28739976) Dimensional psychopathology (Social) ( 29496196) Multiple sclerosis ( 21833088 31604244) Neutrophil count ( 32888494) Systolic blood pressure ( 27618452 27841878)
Interacting Genes		63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32	1 interacting genes: SLC22A1
Entrez ID		8379	55501
HPRD ID		04065	13056
Ensembl ID		ENSG00000002822	ENSG00000136213
Uniprot IDs		Q9Y6D9	Q9NRB3
PDB IDs		1GO4 4DZO 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity	(R)-carnitine Transmembrane Transport Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity Spermidine Transport Metanephric Proximal Tubule Development Epinephrine Transport Norepinephrine:sodium Symporter Activity (R)-carnitine Transport Spermidine Transmembrane Transport Putrescine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity O-acyl-L-carnitine Transmembrane Transport Thiamine Transmembrane Transport Acetylcholine Transmembrane Transporter Activity Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex MAD1 Complex Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Carnitine Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Proximal Tubule Development Carnitine Transmembrane Transport Polyamine Transmembrane Transport Kinetochore Binding Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Positive Regulation Of Mitotic Sister Chromatid Segregation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Amino-acid Betaine Transport Quaternary Ammonium Group Transport Catecholamine Uptake Dopamine Uptake Prostaglandin Transport Serotonin Transport Metanephric Nephron Tubule Development Pyrimidine-containing Compound Transmembrane Transport Nuclear Pore Nuclear Basket Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?