OTUB2 and ARRDC3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OTUB2	ARRDC3
Gene Name		OTU deubiquitinase, ubiquitin aldehyde binding 2	arrestin domain containing 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Endosome Plasma Membrane
	Molecular Function	Ubiquitin-specific Protease Activity	Protein Binding Beta-3 Adrenergic Receptor Binding
	Biological Process	Proteolysis Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Temperature Homeostasis Negative Regulation Of Heat Generation Skin Development Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior
Pathways
Drugs
Diseases
GWAS			Breast cancer (prognosis) ( 23319801) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		33 interactors: APP ARRDC3 CPSF6 FAM168A KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 UBC UBE2N USP21 USP28	14 interactors: BAG3 DCUN1D1 HPGDS ITCH MAGI2 MORF4L1 NEDD4 OTUB2 PDCD6IP STAM2 TNFAIP3 TRIM42 UBE2E2 WWP1
Entrez ID		78990	57561
HPRD ID		07620	09810
Ensembl ID		ENSG00000089723	ENSG00000113369
Uniprot IDs		Q96DC9	Q96B67
PDB IDs		1TFF 4FJV
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Viral Release From Host Cell Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Entry Into Host Cell Regulation Of Signal Transduction Protein Polyubiquitination Regulation Of Viral Entry Into Host Cell Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Cellular Protein Modification Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Cytokine Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune Response Defense Response Regulation Of Viral Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Locomotion Immune System Process I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interferon-gamma Signal Transduction Regulation Of Locomotion Response To Interferon-gamma Negative Regulation Of Viral Transcription Protein Metabolic Process Signaling Regulation Of Cellular Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Deubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Interaction With Host Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Establishment Of Protein Localization To Vacuole Cellular Protein Metabolic Process Proteolysis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Viral Life Cycle Intracellular Receptor Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Entry Into Host Cell Protein Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Type I Interferon Production Cellular Response To Stimulus Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Protein Modification Process Negative Regulation Of Leukocyte Proliferation Cellular Macromolecule Catabolic Process Regulation Of Defense Response To Virus Regulation Of Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Protein Deubiquitination
Tagcloud ?		antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus	adrenergic arrestin arrestins basic beta2 beta2ar capable conformations consists crystal crystallization downregulation electropositive highlights ions ligases lobe lobed motifs nedd4 parallels patch portion ppxy ppyx recruit situation tail thought
Tagcloud (Difference) ?		antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus	adrenergic arrestin arrestins basic beta2 beta2ar capable conformations consists crystal crystallization downregulation electropositive highlights ions lobe lobed motifs nedd4 parallels patch portion ppxy ppyx recruit situation tail thought
Tagcloud (Intersection) ?		ligases