RGMA and CRTC3

Data Source: HiPPIP (Novel)

		RGMA	CRTC3
Name		repulsive guidance molecule BMP co-receptor a	CREB regulated transcription coactivator 3
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Side Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Protein Binding Coreceptor Activity Transferrin Receptor Binding	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Neural Tube Closure Membrane Protein Ectodomain Proteolysis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Primary Metabolic Process	Lipid Catabolic Process Macrophage Activation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Cellular Response To CAMP Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Energy Homeostasis
Pathways		Netrin-1 signaling	Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
GWAS		Blood protein levels ( 30072576 ) Copper levels ( 26025379 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Heel bone mineral density ( 30598549 ) Metabolite levels ( 23823483 ) Opioid dependence ( 29478698 ) Overweight status ( 25133637 ) Periodontitis (CDC/AAP) ( 24024966 ) Refractive error ( 32231278 ) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498 ) Type 1 diabetes nephropathy ( 23028342 ) Type 2 diabetes ( 32499647 )	Apolipoprotein B levels ( 32203549 ) Chromium levels ( 26025379 ) Chronic postoperative pain ( 31903573 ) Colorectal cancer ( 29228715 ) Daytime sleep phenotypes ( 27126917 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Gastroesophageal reflux disease ( 27485664 ) Heel bone mineral density ( 28869591 ) Inflammatory bowel disease ( 23128233 28067908 ) Information processing speed ( 21130836 ) Male-pattern baldness ( 28196072 ) Offspring birth weight ( 31043758 ) Response to exercise (triglyceride level interaction) ( 26491034 ) Ulcerative colitis ( 28067908 )
Novel Interactors		1 novel interactors: CRTC3	8 novel interactors: AEN C15orf32 HAPLN3 RCCD1 RGMA TICRR UNC45A WDR93
Interacting Genes		4 interacting genes: PPP1R16A SGSM2 TERF2IP TP53BP2	5 interacting genes: CA13 KLHL12 SIK2 YAP1 YWHAG
Entrez ID		56963	64784
HPRD ID		09560	13384
Ensembl ID		ENSG00000182175	ENSG00000140577
Uniprot IDs		A0A0A0MTQ4 Q96B86	Q6UUV7
PDB IDs		4UHY 6Z3G	Not available