TNFAIP1 and SVIL

Number of citations of the paper that reports this interaction (PubMedID 20309963)
81

Data Source:
BioGRID (two hybrid)

		TNFAIP1	SVIL
Description		TNF alpha induced protein 1	supervillin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cul3-RING Ubiquitin Ligase Complex	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding Small GTPase Binding Identical Protein Binding	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Immune Response Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development
Pathways		RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 29403010) Osteoprotegerin levels ( 25080503)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		32 interacting genes: ARMC7 ARNT CAPN7 CARD9 CDC37 CSNK2B DAPP1 EPHA2 EPM2AIP1 EXOSC5 FXR1 FXR2 HAT1 HEXIM2 KDM1A LNX1 NTAQ1 NXF1 POLR1C PRKAG1 PSMA1 RHOA RHOB RIN3 SMARCA2 SMARCB1 STK16 SUV39H1 SVIL TRIM54 ZDHHC17 ZMYND19	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		7126	6840
HPRD ID		01856	04992
Ensembl ID		ENSG00000109079	ENSG00000197321
Uniprot IDs		Q13829	A0A6I8PIX7 O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Protein Kinase Regulator Activity Regulation Of Modification Of Synaptic Structure Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cleavage Furrow Positive Regulation Of Cell Development Regulation Of Generation Of Precursor Metabolites And Energy BBAF Complex Epigenetic Regulation Of Gene Expression Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Multicellular Organismal Development Brahma Complex NpBAF Complex Regulation Of Modification Of Postsynaptic Structure Costamere Cytoplasm NBAF Complex Regulation Of Endothelial Cell Migration Protein Binding Translation Regulator Activity Regulation Of Cell Cycle Regulation Of Cell Development Cytoplasmic Stress Granule Postsynapse Epithelial Tube Morphogenesis Positive Regulation Of Cell Differentiation Cytosol Nucleus Regulation Of DNA Repair Blastocyst Hatching Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Size Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of T Cell Differentiation	Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process
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