TNFAIP1 and EPHA2

Number of citations of the paper that reports this interaction (PMID 7536959)
68

Data Source:
HPRD (in vivo)

		TNFAIP1	EPHA2
Gene Name		tumor necrosis factor, alpha-induced protein 1 (endothelial)	EPH receptor A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Cul3-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding GTP-Rho Binding Protein Domain Specific Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	DNA Replication Apoptotic Process Immune Response Embryo Development Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Skeletal System Development Angiogenesis Vasculogenesis Osteoblast Differentiation Cell Adhesion Multicellular Organismal Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Viral Process Cell Migration Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Activation Of Rac GTPase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs			Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		21 interactors: ARMC7 ARNT CAPN7 CARD9 CSNK2B CUL3 EPHA2 EPM2AIP1 EXOSC5 HAT1 KCTD13 KDM1A POLR1C PSMA1 RHOA RHOB RIN3 STK16 SUV39H1 SVIL ZDHHC17	30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A
Entrez ID		7126	1969
HPRD ID		01856	01494
Ensembl ID		ENSG00000109079	ENSG00000142627
Uniprot IDs		Q13829	P29317
PDB IDs			1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Cycle Process Positive Regulation Of Hormone Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Division Response To Stress Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cellular Process Regulation Of Hormone Biosynthetic Process Regulation Of Epithelial Cell Migration Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Intracellular Signal Transduction Chromatin Silencing Regulation Of Hormone Metabolic Process Locomotion Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Erythrocyte Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To External Stimulus Cell Cycle Regulation Of Cell Cycle Process Regulation Of Gene Expression, Epigenetic Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Axonogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Primitive Erythrocyte Differentiation Notochord Cell Development Viral Process Movement Of Cell Or Subcellular Component Axon Development Rho Protein Signal Transduction Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Cell Division	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Locomotion Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Growth Factor Neuron Projection Development Cell Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis Neurotrophin Signaling Pathway Neuron Development Cell Morphogenesis Signal Transduction Regulation Of Signal Transduction Neuron Differentiation Cell Projection Organization Signaling Regulation Of Signaling Cell Communication Fc Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Migration Regulation Of ERBB Signaling Pathway Cell Motility Generation Of Neurons Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Catalytic Activity Neurogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Regulation Of Body Fluid Levels
Tagcloud ?		adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation	abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Difference) ?		adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation	abstract advantages anchor antibody blocks buried cavity cdr consequently crystal deep ephrin ephs forming hydrophobic isolate lengthy library loop mediators phage pocket protrudes reduces reveals stoichiometry technology tip
Tagcloud (Intersection) ?