TNFAIP1 and CAPN7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TNFAIP1	CAPN7
Description		TNF alpha induced protein 1	calpain 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cul3-RING Ubiquitin Ligase Complex	Nucleus Centrosome Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding Small GTPase Binding Identical Protein Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity MIT Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Immune Response Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Proteolysis Positive Regulation Of Epithelial Cell Migration Self Proteolysis
Pathways		RND3 GTPase cycle RND2 GTPase cycle	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 29403010) Osteoprotegerin levels ( 25080503)	Metabolite levels ( 23823483)
Interacting Genes		32 interacting genes: ARMC7 ARNT CAPN7 CARD9 CDC37 CSNK2B DAPP1 EPHA2 EPM2AIP1 EXOSC5 FXR1 FXR2 HAT1 HEXIM2 KDM1A LNX1 NTAQ1 NXF1 POLR1C PRKAG1 PSMA1 RHOA RHOB RIN3 SMARCA2 SMARCB1 STK16 SUV39H1 SVIL TRIM54 ZDHHC17 ZMYND19	19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655
Entrez ID		7126	23473
HPRD ID		01856	05908
Ensembl ID		ENSG00000109079	ENSG00000131375
Uniprot IDs		Q13829	Q7Z479 Q9Y6W3
PDB IDs			2QFE 8UC6
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Protein Kinase Regulator Activity Regulation Of Modification Of Synaptic Structure Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cleavage Furrow Positive Regulation Of Cell Development Regulation Of Generation Of Precursor Metabolites And Energy BBAF Complex Epigenetic Regulation Of Gene Expression Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Multicellular Organismal Development Brahma Complex NpBAF Complex Regulation Of Modification Of Postsynaptic Structure Costamere Cytoplasm NBAF Complex Regulation Of Endothelial Cell Migration Protein Binding Translation Regulator Activity Regulation Of Cell Cycle Regulation Of Cell Development Cytoplasmic Stress Granule Postsynapse Epithelial Tube Morphogenesis Positive Regulation Of Cell Differentiation Cytosol Nucleus Regulation Of DNA Repair Blastocyst Hatching Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Size Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of T Cell Differentiation	Negative Regulation Of Cell Population Proliferation Identical Protein Binding Cell Division Negative Regulation Of Catabolic Process Regulation Of Cell Cycle Centrosome Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cytoplasm Ubiquitin-protein Transferase Activity Negative Regulation Of Autophagy Atrioventricular Valve Morphogenesis Negative Regulation Of Cell Cycle Process Midbody Abscission Regulation Of Primary Metabolic Process Mitotic Cytokinetic Process Mitotic Spindle Protein Ubiquitination Flemming Body Spindle Pole Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytokinetic Process Regulation Of Cell Cycle Process Molecular Adaptor Activity MAD1 Complex Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Heart Valve Morphogenesis Proteasomal Protein Catabolic Process Post-translational Protein Modification Transcription Repressor Complex Protein Stabilization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
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