TNFAIP1 and RHOB

Number of citations of the paper that reports this interaction (PubMedID 33159672)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		TNFAIP1	RHOB
Description		TNF alpha induced protein 1	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cul3-RING Ubiquitin Ligase Complex	Nucleus Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Cleavage Furrow Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding Small GTPase Binding Identical Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Immune Response Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Endosome To Lysosome Transport Positive Regulation Of Endothelial Cell Migration Protein Transport Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation Regulation Of Modification Of Postsynaptic Structure
Pathways		RND3 GTPase cycle RND2 GTPase cycle	GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOB GTPase cycle
Drugs			Botulinum toxin type A
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 29403010) Osteoprotegerin levels ( 25080503)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		32 interacting genes: ARMC7 ARNT CAPN7 CARD9 CDC37 CSNK2B DAPP1 EPHA2 EPM2AIP1 EXOSC5 FXR1 FXR2 HAT1 HEXIM2 KDM1A LNX1 NTAQ1 NXF1 POLR1C PRKAG1 PSMA1 RHOA RHOB RIN3 SMARCA2 SMARCB1 STK16 SUV39H1 SVIL TRIM54 ZDHHC17 ZMYND19	18 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PIAS1 PKN1 PPP2CA RHPN2 ROCK1 RTKN SMURF1 TNFAIP1 UBE2I ZKSCAN5
Entrez ID		7126	388
HPRD ID		01856	01321
Ensembl ID		ENSG00000109079	ENSG00000143878
Uniprot IDs		Q13829	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Protein Kinase Regulator Activity Regulation Of Modification Of Synaptic Structure Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cleavage Furrow Positive Regulation Of Cell Development Regulation Of Generation Of Precursor Metabolites And Energy BBAF Complex Epigenetic Regulation Of Gene Expression Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Multicellular Organismal Development Brahma Complex NpBAF Complex Regulation Of Modification Of Postsynaptic Structure Costamere Cytoplasm NBAF Complex Regulation Of Endothelial Cell Migration Protein Binding Translation Regulator Activity Regulation Of Cell Cycle Regulation Of Cell Development Cytoplasmic Stress Granule Postsynapse Epithelial Tube Morphogenesis Positive Regulation Of Cell Differentiation Cytosol Nucleus Regulation Of DNA Repair Blastocyst Hatching Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Size Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of T Cell Differentiation	Rho Protein Signal Transduction CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Modification Process Protein Geranylgeranyltransferase Activity Cytosol Protein Prenyltransferase Activity Small GTPase Binding Protein Geranylgeranylation Tau Protein Binding Protein Prenylation Prenyltransferase Activity Transferase Activity Mitotic Cytokinesis GTPase Inhibitor Activity Cytoskeleton-dependent Cytokinesis Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process SUMO Transferase Activity Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Cytoskeleton Organization Post-translational Protein Modification Actomyosin Structure Organization Renal System Process Negative Regulation Of Hippo Signaling Apoptotic Process Cytoplasm Regulation Of Protein Localization Cell Death Programmed Cell Death Presynaptic Cytosol Postsynaptic Cytosol Cortical Actin Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Epithelial Cell Migration Regulation Of Signal Transduction Signal Transduction System Process Neuromuscular Junction Development Microtubule Associated Complex Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Cell Surface Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Supramolecular Fiber Organization Protein Modification By Small Protein Conjugation
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