UBQLN2 and OSMR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBQLN2	OSMR
Description		ubiquilin 2	oncostatin M receptor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Plasma Membrane Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Condensate Scaffold Activity	Cytokine Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Regulation Of Macroautophagy ERAD Pathway Negative Regulation Of Transport Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Regulation Of Autophagosome Assembly	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway
Pathways		Cargo recognition for clathrin-mediated endocytosis	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS			Central retinal vein equivalent ( 31597446) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 26192919) Microalbuminuria ( 26631737) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Postoperative survival time in hepatocellular carcinoma ( 30945673 30945699) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908 26192919)
Interacting Genes		246 interacting genes: - ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATP6V1G1 ATXN7 AZGP1 BAG6 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HNRNPA3 HSD17B12 HSPA13 HSPA1B ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LCN1 LCN2 LITAF LMO4 LY6G6D MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMD4 PSORS1C2 PTGDS QPCT RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11 SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 SUOX SUSD4 TBK1 TENT5B TFF3 TIMM21 TIMM44 TIMP2 TMEM123 TNFRSF18 TOMM20L TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	11 interacting genes: GAPDH GPRC5D IL6ST JAK1 JAK2 LHX2 MTDH OSM SGTB SLC10A6 UBQLN2
Entrez ID		29978	9180
HPRD ID		02224	03446
Ensembl ID		ENSG00000188021	ENSG00000145623
Uniprot IDs		Q9UHD9	Q99650
PDB IDs		1J8C 2NBV 6MUN 7F7X
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Humoral Immune Response Collagen Trimer Antimicrobial Humoral Response Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antibacterial Humoral Response Extracellular Matrix Endoplasmic Reticulum Lumen Response To Bacterium Complement Component C1q Complex Protein Targeting To ER Neuropeptide Hormone Activity Establishment Of Protein Localization To Endoplasmic Reticulum Modification-dependent Protein Catabolic Process Complement Activation, Classical Pathway Regulation Of Proteolysis Positive Regulation Of Cell-substrate Adhesion Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell-substrate Adhesion IgM Binding Complement Component C1 Complex Disruption Of Plasma Membrane Integrity In Another Organism Guanylate Cyclase Activator Activity Defense Response To Symbiont Peptidase Inhibitor Activity Defense Response To Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Proteolysis Involved In Protein Catabolic Process Pore-forming Activity Complement Activation Neuropeptide Signaling Pathway Regulation Of Behavior Establishment Of Protein Localization To Organelle Symbiont Cell Surface Peptidyl-prolyl Cis-trans Isomerase Activity Extrinsic Component Of Postsynaptic Membrane Ubiquitin-dependent Protein Catabolic Process Smooth Muscle Cell-matrix Adhesion Cytoplasmic Side Of Late Endosome Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Hormone Activity Cyclosporin A Binding Regulation Of Mononuclear Cell Migration Synapse Pruning K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress	Positive Regulation Of Homotypic Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Binding Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of Acute Inflammatory Response Growth Hormone Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-17 Production Regulation Of Multicellular Organismal Process Regulation Of Platelet Aggregation T Cell Lineage Commitment Positive Regulation Of Cytokine Production Receptor Complex Response To Antibiotic Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Response To Cytokine Response To Peptide Regulation Of Acute Inflammatory Response Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Platelet Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Mesoderm Development Interleukin-35-mediated Signaling Pathway Oncostatin-M Receptor Binding Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Peptidyl-cysteine S-trans-nitrosylation
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