UBQLN2 and RPN1

Number of citations of the paper that reports this interaction (PMID 12200120)
32

Data Source:
HPRD (in vitro, in vivo)

		UBQLN2	RPN1
Gene Name		ubiquilin 2	ribophorin I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome
	Molecular Function	Protein Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Poly(A) RNA Binding
	Biological Process		Translation Cellular Protein Modification Process SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Translation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification SRP-dependent cotranslational protein targeting to membrane Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Monocyte count ( 23314186) White blood cell count ( 21738480)
Protein-Protein Interactions		17 interactors: ADRM1 ATXN7 BTRC C1QA CD93 FAF2 FBXO25 HERC3 HERPUD1 HSPA13 PRPF40A PSMA2 PSMD4 RNF11 RPN1 UBE3A UBQLN4	13 interactors: ADRM1 ASB11 DPF1 ERBB3 HSPA5 RAD23A RBBP4 SGTA SIGIRR UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		29978	6184
HPRD ID		02224	01598
Ensembl ID		ENSG00000188021	ENSG00000163902
Uniprot IDs		B4DZF1 Q9UHD9	P04843
PDB IDs		1J8C
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Viral Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Cellular Protein Modification Process Catabolic Process Positive Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination Positive Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Sperm Entry Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization
Tagcloud ?		als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp vapb vcp	26s adopts atp atph coexisting commitment conformational conformations cryo dataset deconvolutes deubiquitylation em ensemble essentially executes gammas hydrolyzing interpretable landscape lid machine module move polyubiquitylated proteasome rendered static topology
Tagcloud (Difference) ?		als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp vapb vcp	26s adopts atp atph coexisting commitment conformational conformations cryo dataset deconvolutes deubiquitylation em ensemble essentially executes gammas hydrolyzing interpretable landscape lid machine module move polyubiquitylated proteasome rendered static topology
Tagcloud (Intersection) ?