UBQLN2 and QPCT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBQLN2	QPCT
Description		ubiquilin 2	glutaminyl-peptide cyclotransferase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Extracellular Region Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Condensate Scaffold Activity	Protein Binding Zinc Ion Binding Glutaminyl-peptide Cyclotransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Regulation Of Macroautophagy ERAD Pathway Negative Regulation Of Transport Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Regulation Of Autophagosome Assembly	Peptidyl-pyroglutamic Acid Biosynthetic Process, Using Glutaminyl-peptide Cyclotransferase Protein Modification Process
Pathways		Cargo recognition for clathrin-mediated endocytosis	Neutrophil degranulation
Drugs			1-benzylimidazole N-acetylhistamine Glutamine t-butyl ester
Diseases
GWAS			Blood protein levels ( 30072576) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) HDL cholesterol levels in HIV infection ( 33109212) Height ( 31562340) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Schizophrenia ( 23974872 30285260)
Interacting Genes		246 interacting genes: - ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATP6V1G1 ATXN7 AZGP1 BAG6 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HNRNPA3 HSD17B12 HSPA13 HSPA1B ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LCN1 LCN2 LITAF LMO4 LY6G6D MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMD4 PSORS1C2 PTGDS QPCT RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11 SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 SUOX SUSD4 TBK1 TENT5B TFF3 TIMM21 TIMM44 TIMP2 TMEM123 TNFRSF18 TOMM20L TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	2 interacting genes: HRAS UBQLN2
Entrez ID		29978	25797
HPRD ID		02224	06140
Ensembl ID		ENSG00000188021	ENSG00000115828
Uniprot IDs		Q9UHD9	Q16769
PDB IDs		1J8C 2NBV 6MUN 7F7X	2AFM 2AFO 2AFS 2AFU 2AFW 2AFX 2AFZ 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP 3PBB 3PBE 3SI0 4YU9 4YWY 6GBX 6YI1 6YJY 7CM0 7COZ 7CP0 7D8E 8HY3 8XGB 8XGT 8XGY 9ISD 9IVV
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Humoral Immune Response Collagen Trimer Antimicrobial Humoral Response Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antibacterial Humoral Response Extracellular Matrix Endoplasmic Reticulum Lumen Response To Bacterium Complement Component C1q Complex Protein Targeting To ER Neuropeptide Hormone Activity Establishment Of Protein Localization To Endoplasmic Reticulum Modification-dependent Protein Catabolic Process Complement Activation, Classical Pathway Regulation Of Proteolysis Positive Regulation Of Cell-substrate Adhesion Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell-substrate Adhesion IgM Binding Complement Component C1 Complex Disruption Of Plasma Membrane Integrity In Another Organism Guanylate Cyclase Activator Activity Defense Response To Symbiont Peptidase Inhibitor Activity Defense Response To Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Proteolysis Involved In Protein Catabolic Process Pore-forming Activity Complement Activation Neuropeptide Signaling Pathway Regulation Of Behavior Establishment Of Protein Localization To Organelle Symbiont Cell Surface Peptidyl-prolyl Cis-trans Isomerase Activity Extrinsic Component Of Postsynaptic Membrane Ubiquitin-dependent Protein Catabolic Process Smooth Muscle Cell-matrix Adhesion Cytoplasmic Side Of Late Endosome Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Hormone Activity Cyclosporin A Binding Regulation Of Mononuclear Cell Migration Synapse Pruning K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress	Positive Regulation Of Epithelial Cell Proliferation Phospholipase C Activator Activity Regulation Of ERK1 And ERK2 Cascade Oncogene-induced Cell Senescence Regulation Of Neuron Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade GTPase Complex Ripoptosome Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Striated Muscle Atrophy Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Cell Projection Organization Regulation Of Epithelial Cell Proliferation T-helper 1 Type Immune Response Muscle Atrophy Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Schwann Cell Development Response To Nitric Oxide Regulation Of Myoblast Fusion Skeletal Muscle Tissue Regeneration Regulation Of Protein Targeting To Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Tissue Development
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