UBQLN2 and NPY

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBQLN2	NPY
Description		ubiquilin 2	neuropeptide Y
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Condensate Scaffold Activity	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Regulation Of Macroautophagy ERAD Pathway Negative Regulation Of Transport Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Regulation Of Autophagosome Assembly	Response To Yeast Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Adult Feeding Behavior Positive Regulation Of Cell-substrate Adhesion Antibacterial Humoral Response Antifungal Humoral Response Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Regulation Of Nerve Growth Factor Production Monocyte Activation Innate Immune Response Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Short-day Photoperiodism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Intestinal Epithelial Cell Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling Via Neuropeptide Positive Regulation Of Eating Behavior Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Synaptic Vesicle Exocytosis
Pathways		Cargo recognition for clathrin-mediated endocytosis	Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS			Adiponectin levels ( 33562295) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Retinitis pigmentosa ( 33514863) Vitamin D levels ( 25208829)
Interacting Genes		246 interacting genes: - ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATP6V1G1 ATXN7 AZGP1 BAG6 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HNRNPA3 HSD17B12 HSPA13 HSPA1B ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LCN1 LCN2 LITAF LMO4 LY6G6D MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMD4 PSORS1C2 PTGDS QPCT RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11 SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 SUOX SUSD4 TBK1 TENT5B TFF3 TIMM21 TIMM44 TIMP2 TMEM123 TNFRSF18 TOMM20L TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		29978	4852
HPRD ID		02224	01214
Ensembl ID		ENSG00000188021	ENSG00000122585
Uniprot IDs		Q9UHD9	A4D158 P01303
PDB IDs		1J8C 2NBV 6MUN 7F7X	1QFA 1RON 7RTA 7VGX 7X9A 7X9B 7YOO 8K6M 8K6N 8K6O
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Humoral Immune Response Collagen Trimer Antimicrobial Humoral Response Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antibacterial Humoral Response Extracellular Matrix Endoplasmic Reticulum Lumen Response To Bacterium Complement Component C1q Complex Protein Targeting To ER Neuropeptide Hormone Activity Establishment Of Protein Localization To Endoplasmic Reticulum Modification-dependent Protein Catabolic Process Complement Activation, Classical Pathway Regulation Of Proteolysis Positive Regulation Of Cell-substrate Adhesion Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell-substrate Adhesion IgM Binding Complement Component C1 Complex Disruption Of Plasma Membrane Integrity In Another Organism Guanylate Cyclase Activator Activity Defense Response To Symbiont Peptidase Inhibitor Activity Defense Response To Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Proteolysis Involved In Protein Catabolic Process Pore-forming Activity Complement Activation Neuropeptide Signaling Pathway Regulation Of Behavior Establishment Of Protein Localization To Organelle Symbiont Cell Surface Peptidyl-prolyl Cis-trans Isomerase Activity Extrinsic Component Of Postsynaptic Membrane Ubiquitin-dependent Protein Catabolic Process Smooth Muscle Cell-matrix Adhesion Cytoplasmic Side Of Late Endosome Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Hormone Activity Cyclosporin A Binding Regulation Of Mononuclear Cell Migration Synapse Pruning K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress	Neuropeptide Signaling Pathway Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway Feeding Behavior Negative Regulation Of Transport Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity Meprin A Complex Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Regulation Of Feeding Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Signaling Negative Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Communication Regulation Of Eating Behavior Outflow Tract Morphogenesis Synaptic Signaling Via Neuropeptide Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Cardiac Left Ventricle Morphogenesis Positive Regulation Of Digestive System Process Hormone Secretion ERAD Pathway Peptide Transport Regulation Of Response To Food Hormone Transport Regulation Of Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Appetite Synaptic Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Signal Transduction Amide Transport
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