UBQLN2 and LCN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBQLN2	LCN2
Description		ubiquilin 2	lipocalin 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Extracellular Region Extracellular Space Cytoplasmic Vesicle Specific Granule Lumen Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Condensate Scaffold Activity	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Iron Ion Sequestering Activity Enterobactin Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Regulation Of Macroautophagy ERAD Pathway Negative Regulation Of Transport Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Regulation Of Autophagosome Assembly	Immune System Process Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Acute-phase Response Response To Oxidative Stress Short-term Memory Long-term Memory Response To Xenobiotic Stimulus Response To Virus Response To Bacterium Response To Herbicide Response To Toxic Substance Response To Blue Light Response To Fructose Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Response To Nutrient Levels Cellular Response To Nutrient Levels Response To Lipopolysaccharide Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To X-ray Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Kainic Acid Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Cargo recognition for clathrin-mediated endocytosis	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs			Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS
Interacting Genes		246 interacting genes: - ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATP6V1G1 ATXN7 AZGP1 BAG6 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HNRNPA3 HSD17B12 HSPA13 HSPA1B ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LCN1 LCN2 LITAF LMO4 LY6G6D MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMD4 PSORS1C2 PTGDS QPCT RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11 SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 SUOX SUSD4 TBK1 TENT5B TFF3 TIMM21 TIMM44 TIMP2 TMEM123 TNFRSF18 TOMM20L TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF CAMLG CCNC CDSN CHIC2 CIMIP1 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1
Entrez ID		29978	3934
HPRD ID		02224	02551
Ensembl ID		ENSG00000188021	ENSG00000148346
Uniprot IDs		Q9UHD9	P80188
PDB IDs		1J8C 2NBV 6MUN 7F7X	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA 6Z2C 6Z6Z 8UYN 8UZ9
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Humoral Immune Response Collagen Trimer Antimicrobial Humoral Response Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antibacterial Humoral Response Extracellular Matrix Endoplasmic Reticulum Lumen Response To Bacterium Complement Component C1q Complex Protein Targeting To ER Neuropeptide Hormone Activity Establishment Of Protein Localization To Endoplasmic Reticulum Modification-dependent Protein Catabolic Process Complement Activation, Classical Pathway Regulation Of Proteolysis Positive Regulation Of Cell-substrate Adhesion Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell-substrate Adhesion IgM Binding Complement Component C1 Complex Disruption Of Plasma Membrane Integrity In Another Organism Guanylate Cyclase Activator Activity Defense Response To Symbiont Peptidase Inhibitor Activity Defense Response To Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Proteolysis Involved In Protein Catabolic Process Pore-forming Activity Complement Activation Neuropeptide Signaling Pathway Regulation Of Behavior Establishment Of Protein Localization To Organelle Symbiont Cell Surface Peptidyl-prolyl Cis-trans Isomerase Activity Extrinsic Component Of Postsynaptic Membrane Ubiquitin-dependent Protein Catabolic Process Smooth Muscle Cell-matrix Adhesion Cytoplasmic Side Of Late Endosome Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Hormone Activity Cyclosporin A Binding Regulation Of Mononuclear Cell Migration Synapse Pruning K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress	Regulation Of Release Of Cytochrome C From Mitochondria TRC Complex Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Protein-disulfide Reductase Activity Regulation Of ERAD Pathway Protein Targeting To ER Regulation Of Protein Metabolic Process Proteolysis Response To UV Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Response To UV Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Cellular Response To UV-A Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Cellular Response To Light Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Response To UV-A
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