UBQLN2 and LITAF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBQLN2	LITAF
Description		ubiquilin 2	lipopolysaccharide induced TNF factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Condensate Scaffold Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding WW Domain Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Regulation Of Macroautophagy ERAD Pathway Negative Regulation Of Transport Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Regulation Of Autophagosome Assembly	Regulation Of Cytokine Production Regulation Of Macrophage Cytokine Production Response To Lipopolysaccharide Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gallstone disease ( 30504769) Heel bone mineral density ( 30598549) Hip index ( 34021172) Inflammatory bowel disease ( 23128233 28067908) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 32154731) Monocyte percentage of white cells ( 32888494) QT interval ( 19305409 30679814 29874175 29213071 24952745 23166209 19305408) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		246 interacting genes: - ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATP6V1G1 ATXN7 AZGP1 BAG6 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HNRNPA3 HSD17B12 HSPA13 HSPA1B ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LCN1 LCN2 LITAF LMO4 LY6G6D MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMD4 PSORS1C2 PTGDS QPCT RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11 SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 SUOX SUSD4 TBK1 TENT5B TFF3 TIMM21 TIMM44 TIMP2 TMEM123 TNFRSF18 TOMM20L TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205	42 interacting genes: ARID5A ATXN1 BAG3 CALCOCO2 COMT CREB5 DAZAP2 EPN1 EPN2 EPN3 GGA3 HGS HIP1 HPCAL1 HPCAL4 ITCH KCNIP1 KCNIP4 N4BP1 NCALD NEDD4 OPTN POGZ RADIL RASSF3 REEP6 RNF208 RPS27A SMAD2 STAM2 STAT6 TAX1BP1 TNIP1 TNIP3 TOM1 UBA52 UBQLN1 UBQLN2 VENTX VSNL1 WWOX ZIC1
Entrez ID		29978	9516
HPRD ID		02224	10354
Ensembl ID		ENSG00000188021	ENSG00000189067
Uniprot IDs		Q9UHD9	Q99732
PDB IDs		1J8C 2NBV 6MUN 7F7X
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Protein Binding Humoral Immune Response Collagen Trimer Antimicrobial Humoral Response Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antibacterial Humoral Response Extracellular Matrix Endoplasmic Reticulum Lumen Response To Bacterium Complement Component C1q Complex Protein Targeting To ER Neuropeptide Hormone Activity Establishment Of Protein Localization To Endoplasmic Reticulum Modification-dependent Protein Catabolic Process Complement Activation, Classical Pathway Regulation Of Proteolysis Positive Regulation Of Cell-substrate Adhesion Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell-substrate Adhesion IgM Binding Complement Component C1 Complex Disruption Of Plasma Membrane Integrity In Another Organism Guanylate Cyclase Activator Activity Defense Response To Symbiont Peptidase Inhibitor Activity Defense Response To Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Proteolysis Involved In Protein Catabolic Process Pore-forming Activity Complement Activation Neuropeptide Signaling Pathway Regulation Of Behavior Establishment Of Protein Localization To Organelle Symbiont Cell Surface Peptidyl-prolyl Cis-trans Isomerase Activity Extrinsic Component Of Postsynaptic Membrane Ubiquitin-dependent Protein Catabolic Process Smooth Muscle Cell-matrix Adhesion Cytoplasmic Side Of Late Endosome Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Hormone Activity Cyclosporin A Binding Regulation Of Mononuclear Cell Migration Synapse Pruning K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress	Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Cytosol Ubiquitin Binding Regulation Of Macroautophagy Autophagy Clathrin Vesicle Coat Autophagosome Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol Binding Positive Regulation Of Catabolic Process Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization To Vacuole ESCRT-0 Complex Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Cytoplasm Cytoplasmic Vesicle Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Protein Targeting To Lysosome Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Vacuole Endosome Positive Regulation Of Macroautophagy Positive Regulation Of Autophagosome Maturation Import Into Cell Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Early Endosome Membrane Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phospholipid Binding Protein Transport Protein Targeting To Vacuole Regulation Of Protein Deubiquitination Protein Binding Protein Localization To Lysosome Positive Regulation Of Nucleocytoplasmic Transport Protein-containing Complex Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transport Protein Tag Activity Regulation Of Autophagosome Maturation
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