KLF10 and SP1

Number of citations of the paper that reports this interaction (PMID 10976766)
26

Data Source:
HPRD (in vitro)

		KLF10	SP1
Gene Name		Kruppel-like factor 10	Sp1 transcription factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Enhancer Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Peptide	Ossification Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Megakaryocyte Differentiation Lung Development Enucleate Erythrocyte Differentiation Positive Regulation By Host Of Viral Transcription Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways			Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Metabolism of lipids and lipoproteins Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BOP1 CDK6 CRIP2 KAT2B LENG1 LRRC75A-AS1 PIGC RPL14 SF3B3 SIN3A SP1 TNS1 ZNF512B	139 interactors: AATF AHR AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 BTRC C3orf17 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RNF4 RXRA SENP6 SF3A1 SHC1 SKIV2L2 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO1 TAF4 TAL1 TBP TFAP2A TLX3 TP53 TPI1 USP39 VHL YY1 ZBTB16 ZBTB7A
Entrez ID		7071	6667
HPRD ID		03527	01796
Ensembl ID		ENSG00000155090	ENSG00000185591
Uniprot IDs		Q13118	E4Z9M7 G5E9M8 P08047
PDB IDs		2EPA	1SP1 1SP2 1VA1 1VA2 1VA3
Enriched GO Terms of Interacting Partners?		Hematopoietic Progenitor Cell Differentiation Ribosomal Large Subunit Biogenesis Hemopoiesis Immune System Development RNA Metabolic Process Rhythmic Process Response To Methylglyoxal Sequestering Of Nodal From Receptor Via Nodal Binding Cell Dedifferentiation Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Cell Cycle Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Negative Regulation Of Nodal Signaling Pathway Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Chromatin Silencing RRNA Processing RRNA Metabolic Process Notch Signaling Pathway Viral Process Cell Cycle Arrest Determination Of Left/right Asymmetry In Lateral Mesoderm Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Nodal Signaling Pathway Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Maturation Of LSU-rRNA Gene Expression Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Sequestering Of Extracellular Ligand From Receptor Ribosome Biogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Cellular Senescence Cellular Nitrogen Compound Metabolic Process Positive Regulation By Host Of Viral Transcription Fibroblast Migration Regulation Of Protein Glycosylation Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Process Involved In Female Pregnancy DNA-templated Transcription, Initiation N-terminal Protein Amino Acid Acetylation Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Cellular Response To Organic Substance Response To Organic Substance Organ Development Developmental Process Multicellular Organismal Development Anatomical Structure Development Cellular Metabolic Process System Development Regulation Of Cellular Process Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Response To Lipid Tissue Development
Tagcloud ?		acetyltransferase advance antagonistic associate characterize epigenetically foxp3 indeed inducibility inherited integrate integrated interacting kruppel modifying nh2 pcaf physically recapitulated reciprocal renders reporter repressor sin3 studying toggle underlie underlies works
Tagcloud (Difference) ?		acetyltransferase advance antagonistic associate characterize epigenetically foxp3 indeed inducibility inherited integrate integrated interacting kruppel modifying nh2 pcaf physically recapitulated reciprocal renders reporter repressor sin3 studying toggle underlie underlies works
Tagcloud (Intersection) ?