KLF10 and BOP1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KLF10	BOP1
Description		KLF transcription factor 10	BOP1 ribosomal biogenesis factor
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GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Circadian Rhythm Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Population Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Ribosomal Large Subunit Assembly Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Cell Population Proliferation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Chronic lymphocytic leukemia ( 23770605) IgA nephropathy ( 26028593) Liver enzyme levels (alanine transaminase) ( 33972514) Neurofibrillary tangles ( 31497858) Urate levels ( 31578528)	Dupuytren's disease ( 28886342) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Type 2 diabetes ( 30297969)
Interacting Genes		17 interacting genes: BOP1 CDK2 CDK6 CRIP2 FBXW7 KAT2B LENG1 PIGC RPL14 SF3B3 SIAH1 SIN3A SNHG29 SP1 TNS1 TULP3 ZNF512B	2 interacting genes: KLF10 PES1
Entrez ID		7071	23246
HPRD ID		03527	16558
Ensembl ID		ENSG00000155090	ENSG00000261236
Uniprot IDs		Q13118	Q14137
PDB IDs		2EPA	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Rhythmic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Hydroperoxide Nucleolus SAGA Complex Nucleoplasm Histone Acetyltransferase Binding Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Ribosomal Large Subunit Biogenesis Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Y Chromosome Positive Regulation Of Heterochromatin Formation Regulation Of RNA Biosynthetic Process Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Repressor Complex Response To Wortmannin Bronchus Morphogenesis Limb Development Negative Regulation Of RRNA Processing Negative Regulation Of Lipid Biosynthetic Process Histone H3K9 Acetyltransferase Activity Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of Chromatin Organization Regulation Of RNA Metabolic Process Cyclin-dependent Protein Kinase Activity	Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) PeBoW Complex Core Promoter Sequence-specific DNA Binding Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Preribosome, Large Subunit Precursor
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