KLF10 and RPL14

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KLF10	RPL14
Description		KLF transcription factor 10	ribosomal protein L14
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GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Ribosome Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Circadian Rhythm Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Population Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Cytoplasmic Translation RRNA Processing Translation Ribosomal Large Subunit Biogenesis
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Chronic lymphocytic leukemia ( 23770605) IgA nephropathy ( 26028593) Liver enzyme levels (alanine transaminase) ( 33972514) Neurofibrillary tangles ( 31497858) Urate levels ( 31578528)	Neuroticism ( 29255261)
Interacting Genes		17 interacting genes: BOP1 CDK2 CDK6 CRIP2 FBXW7 KAT2B LENG1 PIGC RPL14 SF3B3 SIAH1 SIN3A SNHG29 SP1 TNS1 TULP3 ZNF512B	8 interacting genes: ALG13 FBXO7 KCNK4 KLF10 PEX5 PHLDA1 PTEN TLE6
Entrez ID		7071	9045
HPRD ID		03527	10617
Ensembl ID		ENSG00000155090	ENSG00000188846
Uniprot IDs		Q13118	P50914
PDB IDs		2EPA	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Rhythmic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Hydroperoxide Nucleolus SAGA Complex Nucleoplasm Histone Acetyltransferase Binding Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Ribosomal Large Subunit Biogenesis Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Y Chromosome Positive Regulation Of Heterochromatin Formation Regulation Of RNA Biosynthetic Process Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Repressor Complex Response To Wortmannin Bronchus Morphogenesis Limb Development Negative Regulation Of RRNA Processing Negative Regulation Of Lipid Biosynthetic Process Histone H3K9 Acetyltransferase Activity Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of Chromatin Organization Regulation Of RNA Metabolic Process Cyclin-dependent Protein Kinase Activity	Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Lewy Body Core Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Temperature-gated Cation Channel Activity Response To Arachidonate Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Arachidonate Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Response To Ultrasound Response To Alkaline PH Mechanosensitive Potassium Channel Activity Subcortical Maternal Complex Cytoplasmic Lattice Protein Storage Structural Constituent Of Cytoplasmic Lattice UDP-N-acetylglucosamine Transferase Complex N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Circadian Rhythm Lipid Modification Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Regulation Of Developmental Process Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Multicellular Organismal Development Regulation Of Synaptic Vesicle Clustering Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Cycle G1/S Phase Transition Postsynaptic Density Assembly
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