KLF10 and PIGC

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KLF10	PIGC
Description		KLF transcription factor 10	phosphatidylinositol glycan anchor biosynthesis class C
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Catalytic Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Circadian Rhythm Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Population Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	GPI Anchor Biosynthetic Process
Pathways			Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Chronic lymphocytic leukemia ( 23770605) IgA nephropathy ( 26028593) Liver enzyme levels (alanine transaminase) ( 33972514) Neurofibrillary tangles ( 31497858) Urate levels ( 31578528)	A body shape index ( 34021172) Daytime sleep phenotypes ( 27126917) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		17 interacting genes: BOP1 CDK2 CDK6 CRIP2 FBXW7 KAT2B LENG1 PIGC RPL14 SF3B3 SIAH1 SIN3A SNHG29 SP1 TNS1 TULP3 ZNF512B	4 interacting genes: DPM2 KLF10 PIGQ ZHX1
Entrez ID		7071	5279
HPRD ID		03527	03433
Ensembl ID		ENSG00000155090	ENSG00000135845
Uniprot IDs		Q13118	Q92535
PDB IDs		2EPA
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Rhythmic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Hydroperoxide Nucleolus SAGA Complex Nucleoplasm Histone Acetyltransferase Binding Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Ribosomal Large Subunit Biogenesis Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Y Chromosome Positive Regulation Of Heterochromatin Formation Regulation Of RNA Biosynthetic Process Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Repressor Complex Response To Wortmannin Bronchus Morphogenesis Limb Development Negative Regulation Of RRNA Processing Negative Regulation Of Lipid Biosynthetic Process Histone H3K9 Acetyltransferase Activity Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of Chromatin Organization Regulation Of RNA Metabolic Process Cyclin-dependent Protein Kinase Activity	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Phosphatidylinositol N-acetylglucosaminyltransferase Activity Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Core Promoter Sequence-specific DNA Binding Dolichol-linked Oligosaccharide Biosynthetic Process
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