RELA and CSNK2A1

Number of citations of the paper that reports this interaction (PMID 10938077)
89

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (in vitro, in vivo)

		RELA	CSNK2A1
Gene Name		v-rel avian reticuloendotheliosis viral oncogene homolog A	casein kinase 2, alpha 1 polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol I-kappaB/NF-kappaB Complex	Nucleus Cytosol Plasma Membrane Sin3 Complex NuRD Complex PcG Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Activating Transcription Factor Binding Phosphate Ion Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding NF-kappaB Binding Repressing Transcription Factor Binding Ankyrin Repeat Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Hair Follicle Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Acetaldehyde Metabolic Process Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Defense Response Aging Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Organ Morphogenesis Response To Organic Substance Response To UV-B Positive Regulation Of Schwann Cell Differentiation Viral Process Cytokine-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Response To Progesterone Response To Insulin Response To Cobalamin Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Protein Catabolic Process Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Morphine Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Axon Guidance Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Growth Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Chaperone-mediated Protein Folding Mitotic Spindle Checkpoint
Pathways		Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Interleukin-1 processing Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs			(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Resveratrol 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Benzamidine 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Phosphoaminophosphonic Acid-Adenylate Ester Tetrabromo-2-Benzotriazole DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one N,N\'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 1,2,5,8-tetrahydroxyanthracene-9,10-dione Ellagic Acid
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		185 interactors: AATF ACTL6A AES AGO1 AHR AKAP8 APBA2 AR ASCC1 ASCC2 ASCC3 BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CDC34 CDK9 CEBPB CEBPD CENPJ CHEK1 CHUK CNNM3 COL2A1 COMMD1 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 ECSIT EEF1D EGR1 EP300 ESR1 ETHE1 EZH2 FAF1 FKBP11 FOS FUS GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IKBKB IKBKE IKBKG ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MST1R MTPN MYC NCOA3 NCOA6 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 PARP1 PDCD11 PGR PIAS1 PIAS3 PIN1 PKM PLA2G4A PLK1 PML POU2F1 PPARA PPARG PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RXRA SAT1 SETD7 SIN3A SIRT1 SIRT6 SMAD3 SMAD4 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TNIP2 TP53BP1 TP53BP2 TRIB3 TRIP4 TSC22D3 TWIST1 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A	366 interactors: ABCA1 ACACA ACAT2 ACE ACIN1 AIP AKAP8 AKT1 ALKBH5 ANP32B APC APEX1 APOE APP AQP4 ARL6IP4 ARMCX3 ARNT ARR3 ARRB2 ASIC3 ATF1 ATF2 ATP2B1 ATP5A1 BCLAF1 BDP1 BID BIRC6 BMS1 BRCA1 BRF1 C1orf109 C1R CALM1 CALU CANX CARD9 CASP2 CASQ2 CAV1 CAV2 CCDC6 CD2BP2 CD5 CDC25B CDC37 CDH1 CDK1 CDKN1A CFDP1 CHD4 CHUK CIRBP CLASP2 CLNS1A CLTB COPS2 COPS3 COPS7A CPSF6 CPSF7 CREBBP CREM CSN1S1 CSN2 CSNK2B CTDP1 CTNNB1 CUX2 CXCL8 DDIT3 DDX17 DDX21 DDX24 DDX3X DDX54 DEK DHX16 DHX38 DKC1 DTD1 DVL1 DVL3 EEF1B2 EEF1D EGR1 EIF2B5 EIF2S1 EIF2S2 EIF3J EIF4B EIF4EBP1 EIF5 EIF5B ERH EXOSC9 F11R F5 FAF1 FCP1 FGF1 FGF2 FIBP FIP1L1 FKBP3 FKBP4 FLG FNBP4 FOS FTSJ3 FXR1 GABRR1 GABRR2 GAP43 GGA1 GMFB GMNN GPI GPN1 GTF2A1 GTF2A1L GTF2F1 GYS1 HCLS1 HDAC1 HDAC2 HDAC3 HDGFRP2 HDLBP HES6 HIF1A HIRIP3 HMGA1 HMGA2 HMOX2 HNRNPA2B1 HNRNPC HNRNPDL HNRNPL HOXB7 HSF1 HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPB8 HSPH1 HTATSF1 IFI16 IFRD1 IGF2R IGFBP3 IL16 INF2 IRF2 IRS1 ITCH IWS1 JUN KANK2 KIF1C KIF5C KLF1 KPNA4 L1CAM LARP1 LARP7 LEO1 LGALS3 LIG1 LRRC59 LSM14A LTV1 MAF1 MAGEA11 MAK16 MAPK14 MAPT MAX MAZ MCM2 MCM3 MDC1 MEF2C MFAP1 MGMT MME MPHOSPH10 MRPL38 MRPL4 MS4A1 MSH6 MTDH MYB MYC MYCN MYF5 MYH9 NAF1 NAP1L4 NCAPD2 NCL NCOR1 NFKBIA NFKBIB NFYA NKX2-5 NMD3 NMT1 NOL3 NOLC1 NOP56 NOP58 NPM1 NRF1 NUP98 NXF1 OGT OSBP PACS1 PAFAH1B1 PAK1 PDAP1 PDCD4 PDIA6 PGR PIAS1 PIN1 PIN4 PLEKHO1 PML PNN POLR2A PPAN PPBP PPP1R1B PPP1R2 PPP1R8 PPP2R4 PRCC PRKACB PRNP PRPF38A PRPF40A PSEN2 PSIP1 PSMA3 PSMA4 PTEN PTPN1 PTPRC PURB RANGAP1 RBM10 RBM17 RBM33 RBMX RELA RGS19 RIOK2 RNF111 RNF7 RPL13 RPL5 RPL6 RPLP0 RPLP1 RPRD2 RPS18 RPS3 RPS6KB1 RRAD RRP12 RRP1B RRP9 RSF1 RSL1D1 SAFB SAP30BP SAT1 SCNN1A SEPT2 SERBP1 SERPINF1 SF3A1 SF3B1 SF3B2 SFPQ SHOX SLC18A2 SLC4A1AP SLIRP SMARCC2 SNCA SND1 SNRNP70 SP1 SPATS2L SPI1 SPIB SPP1 SPTBN1 SQSTM1 SREK1 SRF SRRM1 SRRM2 SRRT SRSF10 SRSF11 SRSF2 SSB SSRP1 STAC3 STMN1 STX1A SUB1 SUDS3 SUGT1 SUPT5H SUPT6H SURF6 TCF7L2 TH THAP1 THOC5 THRAP3 TMOD3 TMPO TNKS1BP1 TNP1 TOP1 TOP2A TP53 TSPY1 UBAC1 UBE2R2 UBTF USP24 UTP14A UTP18 VAMP4 VDR VHL VTN WAS WDR44 WDR55 WEE1 XK XKRY XRCC1 XRCC4 XRCC5 XRCC6 XRN2 YBX1 YWHAB YWHAQ ZC3H13 ZC3H15 ZC3H8 ZFC3H1 ZHX1 ZRANB2
Entrez ID		5970	1457
HPRD ID		01241	00277
Ensembl ID		ENSG00000173039
Uniprot IDs		Q04206	P68400
PDB IDs		1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4	1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 4DGL 4FBX 4GRB 4GYW 4GYY 4GZ3 4IB5
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Response To Stress Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Cellular Process Innate Immune Response Regulation Of Protein Metabolic Process Cellular Response To Stress Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Processing Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Processing Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Cellular Process Regulation Of RNA Metabolic Process Response To Stress RNA Splicing Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Developmental Process Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Death Viral Process Cell Death Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process
Tagcloud ?		balpha bbeta bepsilon biochemically casein ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify relb s32 s36 serines	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		balpha bbeta bepsilon biochemically ck complexed conjugation correspond crel ikappa ikappab ikk1 ikks indirectly initiates locate nonstimulated okadaic p100 p105 p90rsk1 pest phosphorylating purify relb s32 s36 serines	bovine catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?		casein