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RELA and CSNK2A2
Number of citations of the paper that reports this interaction (PubMedID
10938077
)
0
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
RELA
CSNK2A2
Description
RELA proto-oncogene, NF-kB subunit
casein kinase 2 alpha 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Protein-containing Complex
NF-kappaB P50/p65 Complex
Synapse
NF-kappaB Complex
Glutamatergic Synapse
Chromatin
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein Kinase CK2 Complex
PcG Protein Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Protein Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Phosphate Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NF-kappaB Binding
Ankyrin Repeat Binding
General Transcription Initiation Factor Binding
DNA-binding Transcription Factor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cytokine Production
Liver Development
Hair Follicle Development
Defense Response To Tumor Cell
Response To Ischemia
Chromatin Organization
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Inflammatory Response
Cellular Defense Response
Neuropeptide Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Bacterium
Animal Organ Morphogenesis
Response To UV-B
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Positive Regulation Of Schwann Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Protein Catabolic Process
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Response To Progesterone
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Response To Insulin
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Protein Sumoylation
Response To Cobalamin
Response To Cytokine
Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Hepatocyte Growth Factor Stimulus
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Vascular Endothelial Growth Factor Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Prolactin Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Response To Morphine
Innate Immune Response
Response To Ethanol
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Inflammatory Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Postsynapse To Nucleus Signaling Pathway
Antiviral Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Amyloid-beta Formation
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Cellular Response To Angiotensin
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Double-strand Break Repair
Apoptotic Process
DNA Damage Response
Spermatogenesis
Wnt Signaling Pathway
Cerebral Cortex Development
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Cell Cycle
Liver Regeneration
Regulation Of Mitophagy
Positive Regulation Of Protein Targeting To Mitochondrion
Regulation Of Chromosome Separation
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
KEAP1-NFE2L2 pathway
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Maturation of hRSV A proteins
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Glucosamine
Dimethyl fumarate
SC-236
[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
Fostamatinib
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol levels (
32203549
)
Sensation seeking (
30718321
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Urate levels (
31578528
31985003
)
Primary biliary cholangitis (
28425483
)
Rosacea symptom severity (
29771307
)
Systemic lupus erythematosus (
28714469
)
Telomere length (
24795349
)
Interacting Genes
205 interacting genes:
AATF
ACTL6A
AGO1
AHR
AKAP8
APBA2
AR
ARNT
ASB9
AURKA
BANP
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CCND2
CDC34
CDK9
CEBPB
CEBPD
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
COMMD10
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
DNMT3L
ECSIT
EEF1D
EGR1
EP300
EPHA2
ESR1
ETHE1
EZH2
FAF1
FBP1
FBXW2
FKBP11
FOS
FUS
GLIS1
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IGF1R
IKBKB
IKBKE
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LATS2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MEOX2
MKRN2
MST1R
MTPN
MX1
MYC
NCOA3
NCOA6
NCOR2
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
OVOL2
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIK3CA
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
POU6F2
PPARA
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
RAD51
RASSF1
RBCK1
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RTN4IP1
RXRA
SAT1
SETD7
SIN3A
SIRT1
SMAD3
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
SUOX
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TLE5
TNIP2
TP53
TP53BP1
TP53BP2
TRIB3
TRIM55
TRIM63
TRIP4
TSC22D3
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
ZBTB7B
104 interacting genes:
ABCA1
ACACA
ADH1A
AQP4
ARRB2
ASL
ATF1
ATF2
ATG16L1
BHLHE41
BID
CABP1
CALM1
CASQ2
CAV1
CDC37
CEBPA
CLTB
CREBBP
CREM
CSN3
CSNK2B
CTDP1
DCPS
DELEC1
EEF1B2
EIF2B2
EIF2B5
EIF4EBP1
ERCC6
ERH
FGF1
FGF2
FKBP3
FOS
GRIN2A
GRIN2B
GTF2A1
GTF2A1L
H1-2
HDAC1
HDAC2
HDAC6
HMGA1
HMGA2
HNRNPC
HSP90AA1
HSP90B1
HSPH1
IL16
KDM1A
KIF1C
KLF1
LAMC3
LGALS3
MAF1
MAPK14
MDM2
MGMT
MS4A1
MYC
MYCN
MYF5
NAP1L4
NCL
NR1D2
P4HB
PAK1
PICK1
PIN1
PIN4
PPP1R1B
PPP1R2
PPP1R8
PRNP
PTEN
PTPN1
PTPRC
RAD1
RAD9A
RELA
RGS19
SAT1
SLC18A2
SMURF1
SNCA
SNX6
SPIB
SPP1
STX1A
TCF7L2
TCOF1
TGFBR1
TGM2
TOP1
TP63
TRIM41
TTLL12
UBE2R2
WAS
XRCC1
ZNF219
ZNF670
ZNHIT3
Entrez ID
5970
1459
HPRD ID
01241
00279
Ensembl ID
ENSG00000173039
ENSG00000070770
Uniprot IDs
A0A087X0W8
Q04206
P19784
PDB IDs
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
5U4K
5URN
6NV2
6QHL
6QHM
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
7BI3
7BIQ
7BIW
7BIY
7BJB
7BJF
7BJL
7BJW
7BKH
7LET
7LEU
7LF4
7NJ9
7NJB
7NK3
7NK5
7NLA
7NLE
7NM1
7NM3
7NM9
7NMH
7NQP
7NR7
7NSV
7NV4
7NVI
7NWS
7NXS
7NXT
7NXW
7NXY
7NY4
7NYE
7NYF
7NYG
7NZ6
7NZG
7NZK
7NZV
7O34
7O3A
7O3F
7O3P
7O3Q
7O3R
7O3S
7O57
7O59
7O5A
7O5C
7O5D
7O5F
7O5G
7O5O
7O5P
7O5S
7O5U
7O5X
7O6F
7O6G
7O6I
7O6J
7O6K
7O6M
7O6O
3E3B
3OFM
3U87
5M4U
5M56
5OOI
5Y9M
5YF9
5YWM
6HMB
6HMC
6HMD
6HMQ
6L20
6QY8
6QY9
6TE2
6TEW
6TGU
7A1B
7A1Z
7A22
7A2H
7AT9
7ATV
7XYH
8Q77
8Q9S
8QBU
8QCD
8QCG
8QF1
Enriched GO Terms of Interacting Partners
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Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Response To Stress
Chromatin
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Chromatin Remodeling
Rhythmic Process
Negative Regulation Of Signal Transduction
Nucleic Acid Metabolic Process
Cytosol
Negative Regulation Of Signaling
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Nucleus
Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Chromatin
Regulation Of Multicellular Organismal Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Intracellular Signaling Cassette
Enzyme Binding
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Response To Alcohol
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Macromolecule Metabolic Process
Protein-containing Complex
Regulation Of Protein Metabolic Process
Nucleoplasm
Regulation Of Cell Communication
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Cellular Response To Stress
Response To Alkaloid
Regulation Of Signaling
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Stress
Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of RNA Metabolic Process
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Tagcloud (Intersection)
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