RELA and AURKA

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RELA	AURKA
Description		RELA proto-oncogene, NF-kB subunit	aurora kinase A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Protein-containing Complex NF-kappaB P50/p65 Complex Synapse NF-kappaB Complex Glutamatergic Synapse	Kinetochore Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Midbody Spindle Pole Centrosome Chromosome Passenger Complex Ciliary Basal Body Germinal Vesicle Cell Projection Neuron Projection Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle Meiotic Spindle Mitotic Spindle Pole Glutamatergic Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peptide Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding NF-kappaB Binding Ankyrin Repeat Binding General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone H3S10 Kinase Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Liver Development Hair Follicle Development Defense Response To Tumor Cell Response To Ischemia Chromatin Organization DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Inflammatory Response Cellular Defense Response Neuropeptide Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Animal Organ Morphogenesis Response To UV-B Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Protein Catabolic Process Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Progesterone Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Protein Sumoylation Response To Cobalamin Response To Cytokine Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Prolactin Signaling Pathway Negative Regulation Of Protein Catabolic Process Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Response To Morphine Innate Immune Response Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Postsynapse To Nucleus Signaling Pathway Antiviral Innate Immune Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Amyloid-beta Formation Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Cellular Response To Angiotensin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Chromatin Remodeling Protein Phosphorylation Apoptotic Process Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Centrosome Cycle Mitotic Centrosome Separation Response To Wounding Anterior/posterior Axis Specification Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Peptidyl-serine Phosphorylation Cell Projection Organization Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Regulation Of Microtubule-based Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Meiotic Cell Cycle Centrosome Localization Cilium Disassembly Protein Localization To Centrosome Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitochondrial Fission Liver Regeneration Positive Regulation Of Oocyte Maturation Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Extension
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA replication proteins TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA
Drugs		Glucosamine Dimethyl fumarate SC-236	Phosphonothreonine AT9283 CYC116 Alisertib SNS-314 Cenisertib Enzastaurin 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE AKI-001 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE Fostamatinib MK-5108 MLN8054
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Sensation seeking ( 30718321) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Urate levels ( 31578528 31985003)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		205 interacting genes: AATF ACTL6A AGO1 AHR AKAP8 APBA2 AR ARNT ASB9 AURKA BANP BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CCND2 CDC34 CDK9 CEBPB CEBPD CHEK1 CHUK CNNM3 COL2A1 COMMD1 COMMD10 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 DNMT3L ECSIT EEF1D EGR1 EP300 EPHA2 ESR1 ETHE1 EZH2 FAF1 FBP1 FBXW2 FKBP11 FOS FUS GLIS1 GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IGF1R IKBKB IKBKE ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LATS2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MEOX2 MKRN2 MST1R MTPN MX1 MYC NCOA3 NCOA6 NCOR2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 OVOL2 PARP1 PDCD11 PGR PIAS1 PIAS3 PIK3CA PIN1 PKM PLA2G4A PLK1 PML POU2F1 POU6F2 PPARA PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 RAD51 RASSF1 RBCK1 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RTN4IP1 RXRA SAT1 SETD7 SIN3A SIRT1 SMAD3 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 SUOX TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TLE5 TNIP2 TP53 TP53BP1 TP53BP2 TRIB3 TRIM55 TRIM63 TRIP4 TSC22D3 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A ZBTB7B	171 interacting genes: AATF AJUBA AKT1 ANGPTL4 ANP32B APP ARPC1B ARPC2 ATRX AUNIP AURKAIP1 BAAT BCL2L1 BEX2 BIRC5 BLID BORA BRAF BRCA1 BTK CBX3 CCND2 CCNE1 CDC20 CDC25B CDH13 CDK8 CEBPA CHFR CKAP5 CORO2A CPEB1 CSN2 CTCFL CYLC2 DACH1 DKK3 EHMT2 EPHA2 EPSTI1 ERBB2 ERRFI1 FANCA FBP2 FOXF1 FOXP1 GADD45A GMNN GSK3B GTF3C4 H3-4 H3C1 HDAC2 HEMGN HIF1A HNRNPF HNRNPK IFI16 IGFBP3 IKBKB KIF11 KIF2C KLHL18 KLK5 LATS2 LEF1 LYPD3 MAP2K1 MAP2K3 MAP3K5 MAPK3 MAPRE2 MAPRE3 MBD3 MBP MDM2 MED26 MTA3 MYC MYT1 MYT1L NANS NAT2 NDC80 NEDD9 NF2 NFKBIA NFXL1 NIN NKX1-1 NME1 NSD2 NUF2 OLA1 OTUB1 PARP10 PAX4 PAX8 PDGFRA PDLIM2 PLK3 PML POU4F3 PPP1CA PPP1CB PPP1CC PPP3R2 PPP6C PRKACA PSEN2 PSMC3IP PSRC1 PTPRD PTTG1 PUM2 RASA1 RASSF1 RELA REST S100A14 SCGB3A1 SEC61B SFRP4 SIN3B SOX18 SOX3 SOX30 SOX4 SREBF2 SRPK1 SRPK2 SSRP1 STAT2 STK11 STX17 SUPT20H SWT1 TACC1 TACC3 TBC1D2 TBX10 TCEAL2 TCERG1 TCF3 TEAD2 TFAP2B TGFB1 THRSP TLK1 TLK2 TP53 TP73 TPX2 TRMO TRRAP TSC1 TSTD2 UBE2C UBE2I UBE2N UBTF USP2 USP21 VHL WIF1 XPA YY1 ZFHX3 ZKSCAN2 ZNF189 ZNF510
Entrez ID		5970	6790
HPRD ID		01241	04066
Ensembl ID		ENSG00000173039	ENSG00000087586
Uniprot IDs		A0A087X0W8 Q04206	O14965
PDB IDs		1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4 5U4K 5URN 6NV2 6QHL 6QHM 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7BI3 7BIQ 7BIW 7BIY 7BJB 7BJF 7BJL 7BJW 7BKH 7LET 7LEU 7LF4 7NJ9 7NJB 7NK3 7NK5 7NLA 7NLE 7NM1 7NM3 7NM9 7NMH 7NQP 7NR7 7NSV 7NV4 7NVI 7NWS 7NXS 7NXT 7NXW 7NXY 7NY4 7NYE 7NYF 7NYG 7NZ6 7NZG 7NZK 7NZV 7O34 7O3A 7O3F 7O3P 7O3Q 7O3R 7O3S 7O57 7O59 7O5A 7O5C 7O5D 7O5F 7O5G 7O5O 7O5P 7O5S 7O5U 7O5X 7O6F 7O6G 7O6I 7O6J 7O6K 7O6M 7O6O	1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 3W10 3W16 3W18 3W2C 4B0G 4BN1 4BYI 4BYJ 4C3P 4C3R 4CEG 4DEA 4DEB 4DED 4DEE 4DHF 4J8M 4J8N 4JAI 4JAJ 4JBO 4JBP 4JBQ 4O0S 4O0U 4O0W 4PRJ 4UYN 4UZD 4UZH 4ZS0 4ZTQ 4ZTR 4ZTS 5AAD 5AAE 5AAF 5AAG 5DN3 5DNR 5DOS 5DPV 5DR2 5DR6 5DR9 5DRD 5DT0 5DT3 5DT4 5EW9 5G15 5G1X 5L8J 5L8K 5L8L 5LXM 5OBJ 5OBR 5ODT 5ONE 5ORL 5ORN 5ORO 5ORP 5ORR 5ORS 5ORT 5ORV 5ORW 5ORX 5ORY 5ORZ 5OS0 5OS1 5OS2 5OS3 5OS4 5OS5 5OS6 5OSD 5OSE 5OSF 5ZAN 6C2R 6C2T 6C83 6CPE 6CPF 6CPG 6GRA 6HJJ 6HJK 6I2U 6R49 6R4A 6R4B 6R4C 6R4D 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA 6Z4Y 7AYH 7AYI 7FIC 7O2V 7ZTL 8C14 8C15 8C1D 8C1E 8C1F 8C1G 8C1H 8C1I 8C1K 8C1M 8GUW 8JF4 8JG8 8JMX 8OF5 8PR7 8SSO 8SSP 9BZG 9BZL
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Chromatin Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Chromatin Remodeling Rhythmic Process Negative Regulation Of Signal Transduction Nucleic Acid Metabolic Process Cytosol Negative Regulation Of Signaling	Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Cell Division Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Chromatin Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Radiation Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Stress Cytoplasm Regulation Of Signal Transduction Anatomical Structure Morphogenesis
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