LTBP1 and FBN1

Number of citations of the paper that reports this interaction (PMID 12429738)
94

Data Source:
HPRD (in vivo, in vitro)

		LTBP1	FBN1
Gene Name		latent transforming growth factor beta binding protein 1	fibrillin 1
Image
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Protein Complex	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Matrix Organization Sequestering Of TGFbeta In Extracellular Matrix	Skeletal System Development Metanephros Development Heart Development Extracellular Matrix Disassembly Extracellular Matrix Organization Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Height ( 20881960 19893584 23563607 20189936) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502)	Breast cancer ( 17903305) Thoracic aortic aneurysms and dissections ( 21909107)
Protein-Protein Interactions		9 interactors: ATN1 CACNA1A FBN1 FBN2 FN1 IGFBP3 ITGB5 TGFB1 TGM2	13 interactors: ATXN7 CALR DCN ELN FBLN2 FBN2 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SPRY2 VCAN
Entrez ID		4052	2200
HPRD ID		01039	00618
Ensembl ID		ENSG00000049323	ENSG00000166147
Uniprot IDs		B7ZLY3 Q14766	P35555
PDB IDs		1KSQ	1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Developmental Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Endoderm Development Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Extracellular Negative Regulation Of Signal Transduction Anatomical Structure Development Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Morphogenesis Endodermal Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myoblast Differentiation Positive Regulation Of Biomineral Tissue Development Salivary Gland Morphogenesis Regulation Of Cell Differentiation Peptide Cross-linking System Development Salivary Gland Development Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Cell Differentiation Endoderm Formation Exocrine System Development Exocytosis Regulation Of Cell Growth Regulation Of Signaling Cellular Component Assembly Platelet Degranulation Regulation Of Bone Mineralization Cellular Metal Ion Homeostasis Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Muscle Cell Differentiation Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Glycosaminoglycan Catabolic Process Organ Development Chondroitin Sulfate Metabolic Process Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Signal Transduction Dermatan Sulfate Biosynthetic Process Negative Regulation Of Signaling Striated Muscle Tissue Development Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Muscle Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Negative Regulation Of Signal Transduction System Development Chondroitin Sulfate Biosynthetic Process Glycoprotein Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Organ Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Multicellular Organismal Development Pathogenesis Skeletal System Development Anatomical Structure Development Proteoglycan Biosynthetic Process Ossification Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Developmental Process Peptide Antigen Assembly With MHC Class I Protein Complex Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sulfur Compound Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Glycoprotein Biosynthetic Process ERBB2 Signaling Pathway
Tagcloud ?		besides bioactive bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		besides bioinformatics btb btbd3 candidate connectivity cul3 degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	additive amounts compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?		bioactive