LTBP1 and FOXN2

Data Source: HiPPIP (Novel)

		LTBP1	FOXN2
Name		latent transforming growth factor beta binding protein 1	forkhead box N2
Structure			No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transforming Growth Factor Beta Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding Microfibril Binding Molecular Adaptor Activity Receptor Ligand Inhibitor Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Establishment Of Protein Localization To Extracellular Region	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation
Pathways		Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	None
GWAS		Appendicular lean mass ( 33097823 ) Arthritis (juvenile idiopathic) ( 34101054 ) Carpal tunnel syndrome ( 30833571 ) Central corneal thickness ( 32528159 29760442 ) Diverticular disease ( 30177863 ) Height ( 28552196 31562340 19893584 20189936 20881960 23563607 25282103 25429064 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Immune response to smallpox vaccine (IL-6) ( 22610502 ) Intraocular pressure ( 29785010 29617998 29235454 ) Knee osteoarthritis ( 30374069 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Male-pattern baldness ( 28196072 ) Optic disc size ( 31809533 ) Rosacea symptom severity ( 29771307 ) Total cholesterol levels ( 33339817 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172 )	Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Bitter alcoholic beverage consumption ( 31046077 ) Chronotype ( 30696823 ) Glycated hemoglobin levels ( 28898252 34059833 ) HDL cholesterol levels ( 32203549 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Left-handedness ( 32989287 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Macular thickness ( 30535121 ) Schizophrenia ( 33169155 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		3 novel interactors: CAD FOXN2 ZFP36L2	1 novel interactors: LTBP1
Interacting Genes		13 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 HOXA1 HTRA1 IGFBP3 IGFBP5 ITGB5 NOTCH3 TGFB1 TGM2	1 interacting genes: USP7
Entrez ID		4052	3344
HPRD ID		01039	00882
Ensembl ID		ENSG00000049323	ENSG00000170802
Uniprot IDs		B7ZLY3 E7EV71 Q14766	P32314
PDB IDs		1KSQ	Not available
GO Terms Enriched among Interactors		Developmental Process Regulation Of Cell Differentiation Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Insulin-like Growth Factor Binding Protein Complex Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Ternary Complex Regulation Of Smooth Muscle Cell Proliferation Growth Factor Binding Lung Alveolus Development Animal Organ Development Insulin-like Growth Factor II Binding Cellular Response To Transforming Growth Factor Beta Stimulus Sequestering Of Extracellular Ligand From Receptor Carbohydrate Homeostasis Glucose Homeostasis Extracellular Region Response To Transforming Growth Factor Beta Extracellular Negative Regulation Of Signal Transduction Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Insulin-like Growth Factor Binding Female Pregnancy Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Tissue Development Microfibril Insulin-like Growth Factor I Binding Positive Regulation Of Smooth Muscle Cell Proliferation Cell Differentiation Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Lumen Response To Peptide Hormone Extracellular Matrix Structural Constituent Response To Growth Factor Anatomical Structure Morphogenesis Response To Hormone Extracellular Space Tube Formation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Embryonic Eye Morphogenesis Negative Regulation Of Cell Differentiation Cell Adhesion Mediated By Integrin Integrin Binding Fibronectin Binding	Extracellular Negative Regulation Of Signal Transduction Sequestering Of Extracellular Ligand From Receptor Microfibril Binding Transforming Growth Factor Beta Receptor Activity Receptor Ligand Inhibitor Activity Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Establishment Of Protein Localization To Chromosome Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere DNA Alkylation Repair Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Transcription-coupled Nucleotide-excision Repair Microfibril Regulation Of Telomere Capping Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Protein-containing Complex K48-linked Deubiquitinase Activity Negative Regulation Of Gluconeogenesis Transforming Growth Factor Beta Binding Deubiquitinase Activity Growth Factor Binding Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Maintenance Of Protein Location Nucleotide-excision Repair Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Cysteine-type Endopeptidase Activity P53 Binding Maintenance Of Location Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Establishment Of Protein Localization To Extracellular Region Extracellular Matrix Structural Constituent Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process Cysteine-type Deubiquitinase Activity Autophagosome Organization Protein Deubiquitination Protein Modification By Small Protein Removal Autophagosome Assembly Regulation Of TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of TOR Signaling