LTBP1 and ZFP36L2

		LTBP1	ZFP36L2
Description		latent transforming growth factor beta binding protein 1	ZFP36 ring finger protein like 2
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GO Annotations	Cellular Component	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex	Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Transforming Growth Factor Beta Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding Microfibril Binding Molecular Adaptor Activity Receptor Ligand Inhibitor Activity	RNA Binding MRNA Binding Protein Binding Zinc Ion Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Establishment Of Protein Localization To Extracellular Region	MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process Response To Wounding Hemopoiesis T Cell Differentiation In Thymus Somatic Stem Cell Population Maintenance Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Negative Regulation Of Fat Cell Differentiation Somatic Stem Cell Division Definitive Hemopoiesis 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Differentiation
Pathways		Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 34101054) Carpal tunnel syndrome ( 30833571) Central corneal thickness ( 32528159 29760442) Diverticular disease ( 30177863) Height ( 28552196 31562340 19893584 20189936 20881960 23563607 25282103 25429064) Hip circumference adjusted for BMI ( 34021172 25673412) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502) Intraocular pressure ( 29785010 29617998 29235454) Knee osteoarthritis ( 30374069) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072) Optic disc size ( 31809533) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 31469255) Estimated glomerular filtration rate ( 31152163) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252) Polycystic ovary syndrome ( 21151128) Red blood cell count ( 32888494 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 HOXA1 HTRA1 IGFBP3 IGFBP5 ITGB5 NOTCH3 TGFB1 TGM2	1 interacting genes: TRIM14
Entrez ID		4052	678
HPRD ID		01039	18319
Ensembl ID		ENSG00000049323	ENSG00000152518
Uniprot IDs		B7ZLY3 E7EV71 Q14766	P47974
PDB IDs		1KSQ	1RGO
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Cell Differentiation Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Insulin-like Growth Factor Binding Protein Complex Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Ternary Complex Regulation Of Smooth Muscle Cell Proliferation Growth Factor Binding Lung Alveolus Development Animal Organ Development Insulin-like Growth Factor II Binding Cellular Response To Transforming Growth Factor Beta Stimulus Sequestering Of Extracellular Ligand From Receptor Carbohydrate Homeostasis Glucose Homeostasis Extracellular Region Response To Transforming Growth Factor Beta Extracellular Negative Regulation Of Signal Transduction Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Insulin-like Growth Factor Binding Female Pregnancy Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Tissue Development Microfibril Insulin-like Growth Factor I Binding Positive Regulation Of Smooth Muscle Cell Proliferation Cell Differentiation Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Lumen Response To Peptide Hormone Extracellular Matrix Structural Constituent Response To Growth Factor Anatomical Structure Morphogenesis Response To Hormone Extracellular Space Tube Formation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Embryonic Eye Morphogenesis Negative Regulation Of Cell Differentiation Cell Adhesion Mediated By Integrin Integrin Binding Fibronectin Binding	Receptor Ligand Inhibitor Activity Phospholipase C Activator Activity GTPase Complex HSP90-CDC37 Chaperone Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Molecular Adaptor Activity Sequestering Of TGFbeta In Extracellular Matrix Oncogene-induced Cell Senescence ATP-dependent Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Aryl Hydrocarbon Receptor Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Telomerase Holoenzyme Complex Assembly Microfibril Binding Transforming Growth Factor Beta Receptor Activity T-helper 1 Type Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Virion Attachment To Host Cell Extracellular Negative Regulation Of Signal Transduction Sequestering Of Extracellular Ligand From Receptor Adhesion Of Symbiont To Host Cell Microfibril Positive Regulation Of Ruffle Assembly Adhesion Of Symbiont To Host Protein Kinase Regulator Activity Histone Methyltransferase Binding Negative Regulation Of Viral Transcription Regulation Of Protein Targeting To Membrane Schwann Cell Development Regulation Of Receptor Localization To Synapse Response To Protozoan Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Ruffle Assembly Cellular Response To Gamma Radiation Defense Response To Protozoan Regulation Of Long-term Neuronal Synaptic Plasticity Axonal Growth Cone Chaperone-mediated Protein Complex Assembly Dynein Axonemal Particle Protein Phosphatase Activator Activity Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Response To Interleukin-4 Peptide Binding Telomere Maintenance Via Telomerase
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