GCGR and GNAS

Number of citations of the paper that reports this interaction (PMID 1908089)
4

Data Source:
HPRD (in vivo)

		GCGR	GNAS
Gene Name		glucagon receptor	GNAS complex locus
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity Peptide Hormone Binding	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Exocytosis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Hormone-mediated Signaling Pathway Glucose Homeostasis Response To Starvation Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog
Drugs		Glucagon recombinant
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: GCG GNAS TGM2 TP63	31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		2642	2778
HPRD ID		00678	00761
Ensembl ID		ENSG00000215644	ENSG00000087460
Uniprot IDs		P47871	O95467 P63092 P84996 Q5JWF2
PDB IDs		3CZF 4ERS 4L6R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Cellular Response To Glucagon Stimulus Multicellular Organismal Water Homeostasis Response To Glucagon Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Hair Follicle Development Hair Cycle Process Positive Regulation Of Ossification Regulation Of CAMP Metabolic Process Hair Cycle Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Epidermal Cell Division Post-embryonic Body Morphogenesis Ectoderm And Mesoderm Interaction Regulation Of Osteoblast Differentiation Chemical Homeostasis Energy Reserve Metabolic Process Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Gland Morphogenesis Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Anatomical Structure Formation Involved In Morphogenesis Limb Morphogenesis Epithelium Development Regulation Of Ossification Regulation Of Insulin Secretion Limb Development G-protein Coupled Receptor Signaling Pathway Regulation Of Epidermal Cell Division Regulation Of Peptide Hormone Secretion Skin Development Morphogenesis Of A Branching Epithelium Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Female Genitalia Morphogenesis Morphogenesis Of A Branching Structure Protein Homooligomerization Regulation Of Hormone Secretion Epidermis Development Homeostatic Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity
Tagcloud ?		atp6v0d2 ctsk gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Difference) ?		atp6v0d2 ctsk gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Intersection) ?