GCGR and GCG

Number of citations of the paper that reports this interaction (PubMedID 8382034)
0

Data Source:
HPRD (in vivo)

		GCGR	GCG
Description		glucagon receptor	glucagon
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Secretory Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity Peptide Hormone Binding	Signaling Receptor Binding Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Cellular Response To Starvation Positive Regulation Of Gene Expression Glucose Homeostasis Response To Starvation Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus	Gluconeogenesis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Response To Activity Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis
Pathways		Glucagon signaling in metabolic regulation G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors	Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin
Drugs		Glucagon Dasiglucagon
Diseases
GWAS		Hematocrit ( 32888494)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		4 interacting genes: GCG GNAS TGM2 TP63	7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B
Entrez ID		2642	2641
HPRD ID		00678	00676
Ensembl ID		ENSG00000215644	ENSG00000115263
Uniprot IDs		P47871	P01275
PDB IDs		2A83 3CZF 4ERS 4L6R 4LF3 5EE7 5XEZ 6LMK 6LML 6WHC 6WPW 7V35 8FU6 8JIQ 8JIT 8JIU 8JRU 8JRV 8WG8 8YW5	1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18 7D68 7DUQ 7KI0 7KI1 7XM8 8ANJ 8ANK 8JRV 9IVG
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Response To Catecholamine Cellular Response To Catecholamine Stimulus Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Survivin Complex Regulation Of Signal Transduction Bone Development Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Ectoderm And Mesoderm Interaction Epidermal Cell Division Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phagocytosis Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Glucagon Receptor Binding Gastric Inhibitory Polypeptide Receptor Binding Mu-type Opioid Receptor Binding Protein Deamination Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Serotonin Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Insulin Secretion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Division Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Cellular Response To Peptide Hormone Stimulus Chemical Homeostasis Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Prostatic Bud Formation	Glucagon Receptor Activity Cellular Response To Glucagon Stimulus Response To Glucagon Meprin A Complex Peptide Hormone Processing Peptide Hormone Binding Signaling Receptor Ligand Precursor Processing Cellular Response To Hormone Stimulus Metallopeptidase Activity Peptidase Activity Regulation Of Hormone Levels Protein Processing Cellular Response To Peptide Hormone Stimulus Hormone Metabolic Process Response To Hormone Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Protein Maturation Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Glucagon-like Peptide 1 Receptor Activity Plasma Membrane G Protein-coupled Receptor Activity Hormone Secretion Metalloendopeptidase Activity Enkephalin Processing Epidermal Growth Factor Receptor Ligand Maturation Hormone Transport Proteolysis Protein Localization To Secretory Granule Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Chromaffin Granule Elastin Metabolic Process Endolysosome Lumen Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Psychosocial Stress Signal Release Regulation Of Blood Pressure Inflammatory Cell Apoptotic Process Extracellular Space Regulation Of Biological Quality Ferric Iron Binding Post-translational Protein Targeting To Membrane, Translocation Metallodipeptidase Activity
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