GCGR

Gene Name		glucagon receptor
Image
Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity Peptide Hormone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Exocytosis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Hormone-mediated Signaling Pathway Glucose Homeostasis Response To Starvation Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation
Drugs		Glucagon recombinant
Diseases
GWAS
Protein-protein Interactions		4 interactors: GCG GNAS TGM2 TP63
Entrez ID		2642
HPRD ID		00678
Ensembl ID		ENSG00000215644
Uniprot IDs		P47871
PDB IDs		3CZF 4ERS 4L6R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Cellular Response To Glucagon Stimulus Multicellular Organismal Water Homeostasis Response To Glucagon Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Hair Follicle Development Hair Cycle Process Positive Regulation Of Ossification Regulation Of CAMP Metabolic Process Hair Cycle Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Epidermal Cell Division Post-embryonic Body Morphogenesis Ectoderm And Mesoderm Interaction Regulation Of Osteoblast Differentiation Chemical Homeostasis Energy Reserve Metabolic Process Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Gland Morphogenesis Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Anatomical Structure Formation Involved In Morphogenesis Limb Morphogenesis Epithelium Development Regulation Of Ossification Regulation Of Insulin Secretion Limb Development G-protein Coupled Receptor Signaling Pathway Regulation Of Epidermal Cell Division Regulation Of Peptide Hormone Secretion Skin Development Morphogenesis Of A Branching Epithelium Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Female Genitalia Morphogenesis Morphogenesis Of A Branching Structure Protein Homooligomerization Regulation Of Hormone Secretion Epidermis Development Homeostatic Process
Tagcloud ?		atp6v0d2 ctsk gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated