STRAP and SNRPD3

Number of citations of the paper that reports this interaction (PMID 15848170)
21

Data Source:
HPRD (in vitro)

		STRAP	SNRPD3
Gene Name		serine/threonine kinase receptor associated protein	small nuclear ribonucleoprotein D3 polypeptide 18kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SMN Complex SMN-Sm Protein Complex	Nucleoplasm Spliceosomal Complex U7 SnRNP U1 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Receptor Binding Protein Binding Poly(A) RNA Binding	Protein Binding Enzyme Binding Poly(A) RNA Binding Histone Pre-mRNA DCP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Histone MRNA Metabolic Process RNA Splicing Gene Expression MRNA 3'-end Processing NcRNA Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Metabolism of non-coding RNA mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs snRNP Assembly Processing of Capped Intronless Pre-mRNA SLBP independent Processing of Histone Pre-mRNAs RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: C6orf203 CHEK2 GEMIN6 GEMIN7 MAP1B NXF1 PBLD PDPK1 RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO4 TGFBR1 TGFBR2	27 interactors: CASP8 CLNS1A CRY1 DDX20 GEMIN2 GEMIN5 GEMIN6 GEMIN7 IL12RB1 IL7R LSM3 LSM7 NR1I3 PRMT5 RBL1 SMN1 SMN2 SNRPB SNRPE SNRPG SNRPN SREK1 STRAP STXBP2 STXBP3 TRDMT1 WDR77
Entrez ID		11171	6634
HPRD ID		05816	03039
Ensembl ID		ENSG00000023734
Uniprot IDs		B0AZV0 B4DNJ6 Q9Y3F4	B4DJP7 P62318
PDB IDs			1D3B 2Y9A 2Y9B 2Y9C 2Y9D 3CW1 3PGW 3VRI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Spliceosomal SnRNP Assembly Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway NcRNA Metabolic Process Ribonucleoprotein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta RNA Processing MRNA Splicing, Via Spliceosome Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Splicing, Via Transesterification Reactions Regulation Of Epithelial To Mesenchymal Transition Cellular Macromolecular Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis RNA Splicing Cellular Response To Growth Factor Stimulus Response To Growth Factor Gene Expression MRNA Processing Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pathway-restricted SMAD Protein Phosphorylation RNA Metabolic Process Embryonic Cranial Skeleton Morphogenesis MRNA Metabolic Process Negative Regulation Of Signaling Spliceosomal Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Regulation Of BMP Signaling Pathway Histone MRNA Metabolic Process Response To Cholesterol Regulation Of Cell Morphogenesis Zygotic Specification Of Dorsal/ventral Axis Activin Receptor Signaling Pathway Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Embryonic Skeletal System Morphogenesis Mesonephros Development Kidney Development Termination Of RNA Polymerase II Transcription Negative Regulation Of Protein Phosphorylation Renal System Development Negative Regulation Of BMP Signaling Pathway	Spliceosomal SnRNP Assembly RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Ribonucleoprotein Complex Assembly RNA Processing MRNA Metabolic Process Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecular Complex Assembly RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Cellular Metabolic Process Histone MRNA Metabolic Process Termination Of RNA Polymerase II Transcription Neutrophil Degranulation Neutrophil Activation Involved In Immune Response DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing Response To Organic Substance Neutrophil Mediated Immunity Neutrophil Activation Cellular Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Metabolic Process Cell Activation Leukocyte Degranulation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulated Secretory Pathway Vesicle Docking Involved In Exocytosis Leukocyte Activation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Negative Regulation Of Glucocorticoid Secretion Blue Light Signaling Pathway
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