STRAP and RNU1-1

Number of citations of the paper that reports this interaction (PubMedID 23221635)
111

Data Source:
BioGRID (unspecified method)

		STRAP	RNU1-1
Description		serine/threonine kinase receptor associated protein	RNA, U1 small nuclear 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SMN Complex SMN-Sm Protein Complex
	Molecular Function	RNA Binding MRNA Binding Signaling Receptor Binding Protein Binding U2 SnRNP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein-RNA Complex Assembly Neuron Differentiation Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Positive Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS
Interacting Genes		31 interacting genes: ANXA1 CEBPA CHEK2 FOXP1 GEMIN6 GEMIN7 MAP1B MTRES1 NEIL3 NXF1 PBLD PDPK1 PTEN RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO2 SUMO4 SZRD1 TGFBR1 TGFBR2	12 interacting genes: DDX20 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PRPF39 RAE1 SMN1 SND1 STRAP
Entrez ID		11171	26871
HPRD ID		05816
Ensembl ID		ENSG00000023734	ENSG00000206652
Uniprot IDs		Q9Y3F4
PDB IDs
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex I-SMAD Binding Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Heteromeric SMAD Protein Complex 7-methylguanosine Cap Hypermethylation SMAD Protein Signal Transduction U2 SnRNP Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein-RNA Complex Assembly Type I Transforming Growth Factor Beta Receptor Binding U4 SnRNP Response To Growth Factor Methylosome Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Small Nuclear Ribonucleoprotein Complex Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway U1 SnRNP Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway U5 SnRNP Regulation Of Epithelial To Mesenchymal Transition RNA Splicing, Via Transesterification Reactions Activin Receptor Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex PICln-Sm Protein Complex Nucleoplasm R-SMAD Binding Regulation Of SMAD Protein Signal Transduction Trophoblast Cell Migration U7 SnRNP U2-type Spliceosomal Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Ureteric Bud Development SMN Complex Ubiquitin Protein Ligase Binding Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Ossification Co-SMAD Binding Gemini Of Cajal Bodies Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA Splicing, Via Spliceosome Mesonephric Tubule Development Mesonephric Epithelium Development SMAD Binding	SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly MRNA Metabolic Process RNA Splicing MRNA Processing RNA Processing RNA Metabolic Process Protein-containing Complex Assembly Nucleic Acid Metabolic Process Protein-containing Complex Organization Nuclear Body RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Spliceosomal Complex Assembly Nucleus Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Binding Nucleoplasm Cytosol Cytoplasm SMN-Gemin2 Complex RNAi Effector Complex Sm-like Protein Family Complex Cajal Body U2 SnRNP Binding U4atac SnRNA Binding Pre-mRNA 5'-splice Site Binding RISC Complex Binding Dense Body Commitment Complex Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery U4 SnRNA Binding RNA Polymerase II Transcription Repressor Complex U1 SnRNA Binding MRNA 5'-splice Site Recognition SnRNA Binding MiRNA Catabolic Process Ribonucleoside Triphosphate Phosphatase Activity RNA 7-methylguanosine Cap Binding
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